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NR4A1 nuclear receptor subfamily 4 group A member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 403897, updated on 28-Sep-2021

Summary

Official Symbol
NR4A1provided by VGNC
Official Full Name
nuclear receptor subfamily 4 group A member 1provided by VGNC
Primary source
VGNC:VGNC:43954
See related
EnsemblRapid:ENSCAFG00845026982
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
NGFI-B
Orthologs
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Genomic context

See NR4A1 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (2944790..2966939, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (43300499..43308433)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (43698715..43706655)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (2961332..2969256, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (2947820..2955733, complement)
105 previous assembly CanFam3.1 (GCF_000002285.3) 27 NC_006609.3 (2947729..2965045, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 41 Neighboring gene autophagy related 101 Neighboring gene trafficking regulator and scaffold protein tamalin Neighboring gene activin A receptor type 1B

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of type B pancreatic cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 4 group A member 1
Names
orphan nuclear receptor HMR
orphan nuclear receptor NGFI-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003227.1NP_001003227.1  nuclear receptor subfamily 4 group A member 1

    See identical proteins and their annotated locations for NP_001003227.1

    Status: PROVISIONAL

    Source sequence(s)
    X97226
    UniProtKB/Swiss-Prot
    P51666
    Related
    ENSCAFP00845037687.1, ENSCAFT00845048033.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    2944790..2966939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038437740.1XP_038293668.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  2. XM_038437744.1XP_038293672.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  3. XM_038437739.1XP_038293667.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  4. XM_038437743.1XP_038293671.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
  5. XM_038437742.1XP_038293670.1  nuclear receptor subfamily 4 group A member 1 isoform X1

    Related
    ENSCAFP00845037598.1, ENSCAFT00845047929.1
    Conserved Domains (2) summary
    cd07348
    Location:361598
    NR_LBD_NGFI-B; The ligand binding domain of Nurr1, a member of conserved family of nuclear receptors
    cd06969
    Location:265339
    NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    2961332..2969256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    2947820..2955733 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    43698715..43706655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    43300499..43308433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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