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COX8 Cytochrome c oxidase subunit 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40390, updated on 27-Mar-2024

Summary

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Official Symbol
COX8provided by FlyBase
Official Full Name
Cytochrome c oxidase subunit 8provided by FlyBase
Primary source
FLYBASE:FBgn0263911
Locus tag
Dmel_CG7181
See related
AllianceGenome:FB:FBgn0263911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0554/18; anon-WO0118547.331; BcDNA:GH15688; CcO VIIc; CG7181; CoVIII; Dmel\CG7181; l(3)S055418; VIII
Summary
Predicted to enable cytochrome-c oxidase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX8A (cytochrome c oxidase subunit 8A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See COX8 in Genome Data Viewer
Location:
78D5-78D5; 3-47 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21538859..21539447, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21531959..21532547, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pickpocket 5 Neighboring gene Regulatory particle non-ATPase 10 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit b Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vectors for Genetically-Encoded Tags for Electron Microscopy Contrast in Drosophila. Tsui MM, et al. Biol Proced Online, 2016. PMID 26839516, Free PMC Article
  2. Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster. Szlanka T, et al. J Cell Sci, 2003 Mar 15. PMID 12584246
  3. Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan. Klichko V, et al. Biochem J, 2014 Apr 1. PMID 24444354
  4. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article
  5. Genetic, functional and evolutionary characterization of scox, the Drosophila melanogaster ortholog of the human SCO1 gene. Porcelli D, et al. Mitochondrion, 2010 Aug. PMID 20388558

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex IV IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome c oxidase subunit 8
Names
CG7181-PA
CG7181-PB
COX8-PA
COX8-PB
cytochrome c oxidase subunit VIII
lethal (3) S055418
subunit VIII

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21538859..21539447 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275240.1 → NP_001262169.1  cytochrome c oxidase subunit 8, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262169.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP19
    Conserved Domains (1) summary
    pfam02285
    Location:26 → 65
    COX8; Cytochrome oxidase c subunit VIII

  2. NM_141071.2 → NP_649328.1  cytochrome c oxidase subunit 8, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649328.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VP19
    Related
    FBpp0078037
    Conserved Domains (1) summary
    pfam02285
    Location:26 → 65
    COX8; Cytochrome oxidase c subunit VIII
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP19 Q9VP19

Gene LinkOut

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