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IL1B interleukin 1 beta [ Canis lupus familiaris (dog) ]

Gene ID: 403974, updated on 5-Mar-2024

Summary

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Official Symbol
IL1Bprovided by VGNC
Official Full Name
interleukin 1 betaprovided by VGNC
Primary source
VGNC:VGNC:41957
See related
Ensembl:ENSCAFG00845011661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
IL-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
7
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 17 NC_051821.1 (37794784..37800390, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 17 NC_006599.4 (36788618..36793136, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 17 NC_049238.1 (37201034..37205552, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 17 NC_049277.1 (36930880..36935397, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 17 NC_049758.1 (36987147..36991665, complement)

Chromosome 17 - NC_051821.1Genomic Context describing neighboring genes Neighboring gene cytoskeleton associated protein 2 like Neighboring gene uncharacterized LOC119869713 Neighboring gene interleukin 1 alpha Neighboring gene sal-like protein 4 Neighboring gene interleukin 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Anti-inflammatory properties and expression in selected organs of canine interleukin-1β splice variant 1. Kiczak L, et al. Vet Immunol Immunopathol, 2015 Oct 15. PMID 26239893
  2. The early inflammatory response after flexor tendon healing: a gene expression and histological analysis. Manning CN, et al. J Orthop Res, 2014 May. PMID 24464937, Free PMC Article
  3. Increased expression of interleukin-1beta and its novel splice variant in canine hearts with volume overload. Kiczak L, et al. Cytokine, 2008 Dec. PMID 19008121
  4. Bacterial production of biologically active canine interleukin-1beta by seamless SUMO tagging and removal. Kirkpatrick RB, et al. Protein Expr Purif, 2006 Nov. PMID 16893658
  5. Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells. Konno T, et al. PLoS One, 2016. PMID 27851800, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the regulation of the expression and function of NGAL in IL-1beta-treated Madin-Darby canine kidney (MDCK) cells, was investigated.
    Title: Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
  2. These findings suggest that stimulation of MEK/ERK signaling pathway by NF-kappaB activation regulates IL-1beta-induced COX-2 expression and subsequent prostaglandin E2 release in canine dermal fibroblasts.
    Title: Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts.
  3. Fatal outcome from pulmonary hemorrhages in dogs with leptospirosis was associated with low TNF-alpha, high IL-1beta, and high iNOS expression.
    Title: Expression Profile of Cytokines and Enzymes mRNA in Blood Leukocytes of Dogs with Leptospirosis and Its Associated Pulmonary Hemorrhage Syndrome.
  4. IL-1beta splice variant 1 (IL-1betasv1) was significantly up-regulated in failing myocardium of dogs suffering from chronic degenerative valvular disease
    Title: Anti-inflammatory properties and expression in selected organs of canine interleukin-1β splice variant 1.
  5. after flexor tendon injury, a greater than 4,000-fold up-regulation in the expression of IL-1beta was observed
    Title: The early inflammatory response after flexor tendon healing: a gene expression and histological analysis.
  6. This study showed that the IL-1Ra:IL-1beta protein ratio was negatively correlated with clinical severity in dogs with inflammatory bowel disease.
    Title: Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease.
  7. canine IL-1beta gene can be transcribed in two ways in heart tissue
    Title: Increased expression of interleukin-1beta and its novel splice variant in canine hearts with volume overload.
  8. mRNA and protein structures and identities of the present known mammalian IL1B.
    Title: Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians.
  9. Inflammatory cytokines and NO may be involved in intraneural inflammatory changes arising from mechanical compression
    Title: Localization and changes of intraneural inflammatory cytokines and inducible-nitric oxide induced by mechanical compression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of immature T cell proliferation in thymus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 beta
Names
IL-1 beta
interleukin-1 beta proprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037971.1 → NP_001033060.1  interleukin-1 beta

    See identical proteins and their annotated locations for NP_001033060.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ251036
    UniProtKB/Swiss-Prot
    Q006K6, Q28292
    UniProtKB/TrEMBL
    A0A8C0KX92, A0A8C0M969, F1PTU3, Q2VCE2
    Related
    ENSCAFP00845016238.1, ENSCAFT00845020705.1
    Conserved Domains (2) summary
    smart00125
    Location:116 → 262
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1 → 100
    IL1_propep; Interleukin-1 propeptide

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051821.1 Reference ROS_Cfam_1.0

    Range
    37794784..37800390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038690464.1 → XP_038546392.1  interleukin-1 beta isoform X1

    UniProtKB/Swiss-Prot
    Q006K6, Q28292
    UniProtKB/TrEMBL
    A0A8C0KX92, A0A8C0M969, F1PTU3, Q2VCE2
    Conserved Domains (2) summary
    smart00125
    Location:116 → 262
    IL1; Interleukin-1 homologues
    pfam02394
    Location:1 → 100
    IL1_propep; Interleukin-1 propeptide

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049277.1 Alternate UMICH_Zoey_3.1

    Range
    36930880..36935397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049758.1 Alternate UNSW_CanFamBas_1.0

    Range
    36987147..36991665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049238.1 Alternate UU_Cfam_GSD_1.0

    Range
    37201034..37205552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006599.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    36788618..36793136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28292.2 GenPept UniProtKB/Swiss-Prot:Q28292

Gene LinkOut

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