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ORMDL Orosomucoid 1-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40404, updated on 10-May-2024

Summary

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Official Symbol
ORMDLprovided by FlyBase
Official Full Name
Orosomucoid 1-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0037110
Locus tag
Dmel_CG14577
See related
AllianceGenome:FB:FBgn0037110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14577; Dmel\CG14577; dORMDL
Summary
Predicted to be involved in cellular sphingolipid homeostasis; ceramide metabolic process; and negative regulation of ceramide biosynthetic process. Located in cytosol. Is expressed in several structures, including adult head; ectodermal derivative; germ band; and imaginal disc. Used to study asthma. Orthologous to human ORMDL1 (ORMDL sphingolipid biosynthesis regulator 1); ORMDL2 (ORMDL sphingolipid biosynthesis regulator 2); and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
78E1-78E1; 3-47 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21635305..21636251)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21628405..21629351)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ALG11, alpha-1,2-mannosyltransferase Neighboring gene Mediator complex subunit 1 Neighboring gene antisense RNA:CR45955 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In utero exposure to cigarette smoke and effects across generations: A conference of animals on asthma. Hammer B, et al. Clin Exp Allergy, 2018 Nov. PMID 30244507
  2. ORMDL proteins are a conserved new family of endoplasmic reticulum membrane proteins. Hjelmqvist L, et al. Genome Biol, 2002. PMID 12093374, Free PMC Article
  3. ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways. Kallsen K, et al. J Allergy Clin Immunol, 2015 Oct. PMID 25979522
  4. Sphingolipids in neurodegenerative diseases. Pan X, et al. Front Neurosci, 2023. PMID 36875645, Free PMC Article
  5. Drosophila in asthma research. Roeder T, et al. Am J Respir Crit Care Med, 2009 Jun 1. PMID 19342413

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.
    Title: ORMDL deregulation increases stress responses and modulates repair pathways in Drosophila airways.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in ceramide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular sphingolipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SPOTS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
orosomucoid 1-like
Names
CG14577-PA
ORMDL-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21635305..21636251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168929.2 → NP_730669.1  orosomucoid 1-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0JQ27, Q8MX27, Q9VP04
    UniProtKB/TrEMBL
    A0A1B2AK17
    Related
    FBpp0078077
    Conserved Domains (1) summary
    pfam04061
    Location:12 → 147
    ORMDL; ORMDL family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VP04.1 Q9VP04

Gene LinkOut

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