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Sfxn1-3 Sideroflexin 1/3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40552, updated on 11-Apr-2024

Summary

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Official Symbol
Sfxn1-3provided by FlyBase
Official Full Name
Sideroflexin 1/3provided by FlyBase
Primary source
FLYBASE:FBgn0037239
Locus tag
Dmel_CG11739
See related
AllianceGenome:FB:FBgn0037239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey55; CG11739; Dmel\CG11739; Sfxn3
Summary
Enables serine transmembrane transporter activity. Involved in serine import into mitochondrion. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Orthologous to human SFXN1 (sideroflexin 1) and SFXN3 (sideroflexin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
82A5-82A5; 3-47.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4378600..4381210)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (204322..206932)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44922 Neighboring gene Contactin Neighboring gene tube

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo. Ledahawsky LM, et al. FEBS J, 2022 Jul. PMID 35092170, Free PMC Article
  2. Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry. Minjarez B, et al. J Proteomics, 2016 Apr 29. PMID 27012543
  3. Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function. Faivre-Sarrailh C, et al. Development, 2004 Oct. PMID 15459097
  4. SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism. Kory N, et al. Science, 2018 Nov 16. PMID 30442778, Free PMC Article
  5. Adaptive evolution of genes duplicated from the Drosophila pseudoobscura neo-X chromosome. Meisel RP, et al. Mol Biol Evol, 2010 Aug. PMID 20351054, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables L-serine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of one-carbon metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serine import into mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in serine import into mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sideroflexin 1/3
Names
CG11739-PA
CG11739-PB
CG11739-PC
CG11739-PD
Sfxn1-3-PA
Sfxn1-3-PB
Sfxn1-3-PC
Sfxn1-3-PD
sideroflexin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    4378600..4381210
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141203.4 → NP_649460.3  sideroflexin 1/3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649460.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN13
    Related
    FBpp0078554
    Conserved Domains (1) summary
    pfam03820
    Location:14 → 321
    Mtc; Tricarboxylate carrier

  2. NM_164347.3 → NP_730823.2  sideroflexin 1/3, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730823.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN13
    Related
    FBpp0078553
    Conserved Domains (1) summary
    pfam03820
    Location:14 → 321
    Mtc; Tricarboxylate carrier

  3. NM_164345.3 → NP_730821.2  sideroflexin 1/3, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730821.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN13
    Related
    FBpp0078555
    Conserved Domains (1) summary
    pfam03820
    Location:14 → 321
    Mtc; Tricarboxylate carrier

  4. NM_164346.3 → NP_730822.2  sideroflexin 1/3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730822.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VN13
    Related
    FBpp0078556
    Conserved Domains (1) summary
    pfam03820
    Location:14 → 321
    Mtc; Tricarboxylate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VN13.1 Q9VN13

Gene LinkOut

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