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POLDIP2 Polymerase (DNA-directed), delta interacting protein 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40655, updated on 10-May-2024

Summary

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Official Symbol
POLDIP2provided by FlyBase
Official Full Name
Polymerase (DNA-directed), delta interacting protein 2provided by FlyBase
Primary source
FLYBASE:FBgn0037329
Locus tag
Dmel_CG12162
See related
AllianceGenome:FB:FBgn0037329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12162; Dmel\CG12162
Summary
Predicted to enable DNA binding activity. Predicted to be involved in error-free translesion synthesis. Predicted to be active in mitochondrial nucleoid and nucleus. Is expressed in adult head; adult heart; and embryonic/larval midgut. Orthologous to human POLDIP2 (DNA polymerase delta interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See POLDIP2 in Genome Data Viewer
Location:
83A4-83A4; 3-47.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5467778..5469566)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1293500..1295288)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pancreatic eIF-2alpha kinase Neighboring gene Ribosomal protein L35A Neighboring gene mitochondrial ribosomal protein L44 Neighboring gene Snf5-related 1 Neighboring gene uncharacterized protein Neighboring gene Histone deacetylase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential role of POLDIP2 in Tau aggregation and neurotoxicity via autophagy/proteasome inhibition. Kim Y, et al. Biochem Biophys Res Commun, 2015 Jun 26. PMID 25930997
  2. Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila. Svensson MJ, et al. Dev Genes Evol, 2007 Sep. PMID 17701050
  3. A set of structural features defines the cis-regulatory modules of antenna-expressed genes in Drosophila melanogaster. López Y, et al. PLoS One, 2014. PMID 25153327, Free PMC Article
  4. Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators. Kwon SY, et al. PLoS Genet, 2016 Apr. PMID 27046080, Free PMC Article
  5. Seizure suppression through manipulating splicing of a voltage-gated sodium channel. Lin WH, et al. Brain, 2015 Apr. PMID 25681415, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polymerase (DNA-directed), delta interacting protein 2
Names
CG12162-PA
CG12162-PB
POLDIP2-PA
POLDIP2-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    5467778..5469566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141283.4 → NP_649540.1  polymerase (DNA-directed), delta interacting protein 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649540.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VNC0
    Related
    FBpp0078329
    Conserved Domains (2) summary
    pfam04379
    Location:287 → 369
    DUF525; Protein of unknown function (DUF525)
    cl01548
    Location:51 → 237
    YccV-like; Hemimethylated DNA-binding protein YccV like

  2. NM_169054.2 → NP_730934.1  polymerase (DNA-directed), delta interacting protein 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730934.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IPQ6
    Related
    FBpp0078330
    Conserved Domains (2) summary
    pfam04379
    Location:308 → 390
    DUF525; Protein of unknown function (DUF525)
    cl01548
    Location:72 → 258
    YccV-like; Hemimethylated DNA-binding protein YccV like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IPQ6 Q8IPQ6
Q9VNC0 Q9VNC0

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