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EGR1 early growth response 1 [ Bos taurus (cattle) ]

Gene ID: 407125, updated on 5-Mar-2024

Summary

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Official Symbol
EGR1provided by VGNC
Official Full Name
early growth response 1provided by VGNC
Primary source
VGNC:VGNC:52766
See related
BGD:BT24351; Ensembl:ENSBTAG00000010069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (49826725..49829568)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 3B Neighboring gene uncharacterized LOC101904825 Neighboring gene receptor accessory protein 2 Neighboring gene POU domain, class 5, transcription factor 1-like Neighboring gene eukaryotic translation termination factor 1 Neighboring gene small nucleolar RNA SNORD63 Neighboring gene heat shock protein family A (Hsp70) member 9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Expression of EGR1 gene and location of EGR1 protein in differentiation of bovine skeletal muscle-derived satellite cells]. Zhang WW, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi, 2019 Jan. PMID 31245944
  2. Regulation and action of early growth response 1 in bovine granulosa cells. Han P, et al. Reproduction, 2017 Oct. PMID 28733346
  3. Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation. Sayasith K, et al. J Mol Endocrinol, 2006 Oct. PMID 17032742
  4. Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. Banks MF, et al. J Appl Physiol (1985), 2005 Feb. PMID 15475598
  5. Cellular microRNA bta-miR-2361 inhibits bovine herpesvirus 1 replication by directly targeting EGR1 gene. Hou P, et al. Vet Microbiol, 2019 Jun. PMID 31176405

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. During the differentiation of bovine skeletal muscle satellite cells, the transcriptional level of EGR1 gene is increased, and some EGR1 proteins are transferred into the nucleus.
    Title: [Expression of EGR1 gene and location of EGR1 protein in differentiation of bovine skeletal muscle-derived satellite cells].
  2. This is the first study to reveal that bta-miR-2361 as a novel host factor regulates Bovine herpesvirus 1 replication via directly targeting the EGR1 gene.
    Title: Cellular microRNA bta-miR-2361 inhibits bovine herpesvirus 1 replication by directly targeting EGR1 gene.
  3. EGR1 is a major upstream component of FGF signaling in theca cells and that it directs cell fate toward proliferation.
    Title: Effects of fibroblast growth factors and the transcription factor, early growth response 1, on bovine theca cells.
  4. Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells.
    Title: Regulation and action of early growth response 1 in bovine granulosa cells.
  5. EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression.
    Title: Transcription factor EGR1 promotes differentiation of bovine skeletal muscle satellite cells by regulating MyoG gene expression.
  6. Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling.
    Title: Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.
  7. The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells.
    Title: Egr-1 antisense oligonucleotides inhibit hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts.
  8. EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle.
    Title: Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC139820

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
early growth response protein 1
Names
EGR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045875.1 → NP_001039340.1  early growth response protein 1

    See identical proteins and their annotated locations for NP_001039340.1

    Status: PROVISIONAL

    Source sequence(s)
    AY924307
    UniProtKB/Swiss-Prot
    Q29W20
    UniProtKB/TrEMBL
    Q17QJ4
    Related
    ENSBTAP00000013284.5, ENSBTAT00000013284.7
    Conserved Domains (6) summary
    sd00017
    Location:339 → 361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:337 → 361
    zf-C2H2; Zinc finger, C2H2 type
    pfam05687
    Location:436 → 502
    BES1_N; BES1/BZR1 plant transcription factor, N-terminal
    pfam11914
    Location:444 → 527
    DUF3432; Domain of unknown function (DUF3432)
    pfam11928
    Location:135 → 208
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:380 → 405
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    49826725..49829568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q29W20.1 GenPept UniProtKB/Swiss-Prot:Q29W20

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
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