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USF1 upstream transcription factor 1 [ Bos taurus (cattle) ]

Gene ID: 407239, updated on 5-Jun-2024

Summary

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Official Symbol
USF1provided by VGNC
Official Full Name
upstream transcription factor 1provided by VGNC
Primary source
VGNC:VGNC:55695
See related
Ensembl:ENSBTAG00000017873
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See USF1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 3 NC_037330.1 (8436862..8442550)

Chromosome 3 - NC_037330.1Genomic Context describing neighboring genes Neighboring gene nectin cell adhesion molecule 4 Neighboring gene Rho GTPase activating protein 30 Neighboring gene uncharacterized LOC132344818 Neighboring gene thiosulfate sulfurtransferase like domain containing 1 Neighboring gene F11 receptor Neighboring gene small ribosomal subunit protein uS10-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development. Datta TK, et al. Reproduction, 2015 Feb. PMID 25385722, Free PMC Article
  2. Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene. Fürbass R, et al. BMC Mol Biol, 2010 Jan 18. PMID 20082704, Free PMC Article
  3. Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells. Sayasith K, et al. J Biol Chem, 2004 Feb 20. PMID 14660559
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study demonstrates that upstream transcription factor 1 (USF1) is a maternally derived transcription factor required for bovine early embryonic development
    Title: Requirement of the transcription factor USF1 in bovine oocyte and early embryonic development.
  2. Depletion of the USFs by RNAi and expression of a dominant-negative USF mutant, were both associated with a significant decrease in P1.1-dependent reporter gene expression.
    Title: Upstream stimulating factors 1 and 2 enhance transcription from the placenta-specific promoter 1.1 of the bovine cyp19 gene.
  3. bovine upstream stimulatory factor 1 and 2 have roles regulating the prostaglandin G/H synthase-2 promoter in granulosa cells [USF1/USF2]
    Title: Molecular characterization and role of bovine upstream stimulatory factor 1 and 2 in the regulation of the prostaglandin G/H synthase-2 promoter in granulosa cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC137781

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
upstream stimulatory factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001161.2 → NP_001001161.1  upstream stimulatory factor 1

    See identical proteins and their annotated locations for NP_001001161.1

    Status: PROVISIONAL

    Source sequence(s)
    BC114684
    UniProtKB/Swiss-Prot
    Q6XBT4
    Related
    ENSBTAP00000023760.5, ENSBTAT00000023760.6
    Conserved Domains (1) summary
    cd18924
    Location:196 → 260
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037330.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    8436862..8442550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024985344.2 → XP_024841112.1  upstream stimulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6XBT4
    Conserved Domains (1) summary
    cd18924
    Location:196 → 260
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

  2. XM_024985356.2 → XP_024841124.1  upstream stimulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6XBT4
    Conserved Domains (1) summary
    cd18924
    Location:196 → 260
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

  3. XM_024985340.2 → XP_024841108.1  upstream stimulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6XBT4
    Conserved Domains (1) summary
    cd18924
    Location:196 → 260
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

  4. XM_024985378.2 → XP_024841146.1  upstream stimulatory factor 1 isoform X3

    Conserved Domains (1) summary
    cd18924
    Location:135 → 199
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

  5. XM_024985349.2 → XP_024841117.1  upstream stimulatory factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q6XBT4
    Conserved Domains (1) summary
    cd18924
    Location:196 → 260
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins

  6. XM_024985366.2 → XP_024841134.1  upstream stimulatory factor 1 isoform X2

    Conserved Domains (1) summary
    cd18924
    Location:137 → 201
    bHLHzip_USF1; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 1 (USF1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6XBT4.1 GenPept UniProtKB/Swiss-Prot:Q6XBT4

Gene LinkOut

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