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Kb23 type II keratin 23 [ Rattus norvegicus (Norway rat) ]

Gene ID: 407759, updated on 19-Jan-2022

Summary

Official Symbol
Kb23provided by RGD
Official Full Name
type II keratin 23provided by RGD
Primary source
RGD:1303024
See related
Ensembl:ENSRNOG00000030814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in intermediate filament-based process. Predicted to be located in keratin filament. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 5; hair disease; and monilethrix. Orthologous to several human genes including KRT81 (keratin 81); KRT83 (keratin 83); and KRT86 (keratin 86). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward (RPKM 30.5) See more
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Genomic context

See Kb23 in Genome Data Viewer
Location:
7q36
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132604180..132610869, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143134980..143141659, complement)

Chromosome 7 - NC_051342.1Genomic Context describing neighboring genes Neighboring gene keratin 81 Neighboring gene keratin 86 Neighboring gene keratin 85 Neighboring gene keratin 84

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intermediate filament-based process TAS
Traceable Author Statement
more info
PubMed 
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in intermediate filament TAS
Traceable Author Statement
more info
PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in keratin filament TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
type II keratin 23
Names
type II keratin Kb23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389278.1NP_001376207.1  type II keratin 23

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000187
    Related
    ENSRNOP00000059981.3, ENSRNOT00000068505.4
    Conserved Domains (2) summary
    pfam00038
    Location:103414
    Filament; Intermediate filament protein
    pfam16208
    Location:4100
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051342.1 Reference mRatBN7.2 Primary Assembly

    Range
    132604180..132610869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079712.1XP_038935640.1  type II keratin 23 isoform X1

    Conserved Domains (1) summary
    pfam00038
    Location:2230
    Filament; Intermediate filament protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008813.1: Suppressed sequence

    Description
    NM_001008813.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
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