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HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 [ Bos taurus (cattle) ]

Gene ID: 407767, updated on 3-Apr-2024

Summary

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Official Symbol
HMGCS1provided by VGNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 1provided by VGNC
Primary source
VGNC:VGNC:29880
See related
BGD:BT17828; Ensembl:ENSBTAG00000011839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 20 NC_037347.1 (31431132..31456871)

Chromosome 20 - NC_037347.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 267 Neighboring gene C-C motif chemokine ligand 28 Neighboring gene NIM1 serine/threonine protein kinase Neighboring gene uncharacterized LOC112443002 Neighboring gene small nucleolar RNA SNORA65

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037347.1 Chromosome 20 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and physical mapping of genes expressed in the corpus luteum in cattle. Bønsdorff T, et al. Anim Genet, 2003 Oct. PMID 14510667
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA synthase, cytoplasmic
Names
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS1 protein-like
NP_001193507.1
XP_059734659.1
XP_059734660.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206578.1 → NP_001193507.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic

    See identical proteins and their annotated locations for NP_001193507.1

    Status: VALIDATED

    Source sequence(s)
    DT814755, EE224192, EE350662, EV627373, NKLS02000020
    UniProtKB/TrEMBL
    A0A3Q1LPX4, Q3ZC79
    Related
    ENSBTAP00000015713.4, ENSBTAT00000015713.5
    Conserved Domains (1) summary
    TIGR01833
    Location:13 → 469
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037347.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    31431132..31456871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059878676.1 → XP_059734659.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X1

    Related
    ENSBTAP00000057020.2, ENSBTAT00000085392.2

  2. XM_059878677.1 → XP_059734660.1  hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LPX4
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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