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Znrf3 zinc and ring finger 3 [ Mus musculus (house mouse) ]

Gene ID: 407821, updated on 21-Apr-2024

Summary

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Official Symbol
Znrf3provided by MGI
Official Full Name
zinc and ring finger 3provided by MGI
Primary source
MGI:MGI:3039616
See related
Ensembl:ENSMUSG00000041961 AllianceGenome:MGI:3039616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1167
Summary
Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in vibrissa. Orthologous to human ZNRF3 (zinc and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 4.8), thymus adult (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 3.46 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5226329..5394847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5276329..5444847, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene kringle containing transmembrane protein 1 Neighboring gene predicted gene, 46268 Neighboring gene predicted gene, 30172 Neighboring gene STARR-seq mESC enhancer starr_28426 Neighboring gene STARR-seq mESC enhancer starr_28427 Neighboring gene STARR-positive B cell enhancer ABC_E8384 Neighboring gene STARR-seq mESC enhancer starr_28430 Neighboring gene STARR-seq mESC enhancer starr_28431 Neighboring gene STARR-seq mESC enhancer starr_28432 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5400351-5400552 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:5401062-5401263 Neighboring gene STARR-seq mESC enhancer starr_28434 Neighboring gene predicted gene 11963 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9357 Neighboring gene X-box binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways. Liang JJ, et al. Inflammation, 2020 Jun. PMID 32125593
  2. Sexually dimorphic activation of innate antitumor immunity prevents adrenocortical carcinoma development. Wilmouth JJ Jr, et al. Sci Adv, 2022 Oct 14. PMID 36240276, Free PMC Article
  3. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation. Sun T, et al. Cell Stem Cell, 2021 Oct 7. PMID 34129813
  4. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis. Lu C, et al. Stem Cell Reports, 2022 Feb 8. PMID 34995498, Free PMC Article
  5. Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3. Zebisch M, et al. J Struct Biol, 2015 Aug. PMID 26123262, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
    Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
  2. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
    Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
  3. ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways.
    Title: ZNRF3 Regulates Collagen-Induced Arthritis Through NF-kB and Wnt Pathways.
  4. adrenocortical-specific loss of ZNRF3, but not RNF43, results in adrenal hyperplasia that depends on Porcupine-mediated Wnt ligand secretion.
    Title: A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis.
  5. XY mice lacking ZNRF3 exhibit complete or partial gonadal sex reversal, or related defects.
    Title: ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.
  6. RSPO-LGR4/5-ZNRF3/RNF43 module controls metabolic liver zonation and is a hepatic growth/size rheostat during development, homeostasis and regeneration.
    Title: The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size.
  7. Crystal structure confirming that Rspo proteins cross-link LGRs and ZNRF3 into a 2:2:2 complex.
    Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
  8. ZNRF3 binds RSPO1 and LGR5-RSPO1 with micromolar affinity via RSPO1 furin-like 1 (Fu1) domain.
    Title: Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
  9. data suggest that R-spondin enhances Wnt signalling by inhibiting ZNRF3
    Title: ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt receptor catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt receptor catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ZNRF3
Names
RING-type E3 ubiquitin transferase ZNRF3
zinc/RING finger protein 3
NP_001074393.1
NP_001277430.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080924.2 → NP_001074393.1  E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001074393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL662853, AL662876
    Consensus CDS
    CCDS36102.1
    UniProtKB/Swiss-Prot
    B2RXA5, Q3V095, Q5SSZ7
    Related
    ENSMUSP00000105493.2, ENSMUST00000109867.8
    Conserved Domains (1) summary
    pfam13639
    Location:289 → 331
    zf-RING_2; Ring finger domain

  2. NM_001290501.1 → NP_001277430.1  E3 ubiquitin-protein ligase ZNRF3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding sequence, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK133342, AL662853
    Consensus CDS
    CCDS70134.1
    UniProtKB/Swiss-Prot
    Q5SSZ7
    Related
    ENSMUSP00000134698.2, ENSMUST00000172492.8
    Conserved Domains (1) summary
    pfam13639
    Location:193 → 235
    zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    5226329..5394847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SSZ7.1 GenPept UniProtKB/Swiss-Prot:Q5SSZ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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