cpe carboxypeptidase E [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cpeprovided by ZNC
Official Full Name: carboxypeptidase Eprovided by ZNC
Primary source: ZFIN:ZDB-GENE-090313-68
See related: Ensembl:ENSDARG00000055874 AllianceGenome:ZFIN:ZDB-GENE-090313-68
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85981; si:ch211-198g9.2
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space. Is expressed in posterior pancreatic bud and retina. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (20866858..20911278, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (20173921..20218393, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G39583 (e-PCR)
- UniSTS:8740

G46781 (e-PCR)
- UniSTS:107578

fj09b03.x1 (e-PCR)
- UniSTS:198477

fc44a03.x1 (e-PCR)
- UniSTS:193871

fb51h10.x1 (e-PCR)
- UniSTS:190661

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxypeptidase E

NP_999975.1

EC 3.4.17.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214810.2 → NP_999975.1 carboxypeptidase E precursor

See identical proteins and their annotated locations for NP_999975.1

Status: VALIDATED

Source sequence(s)

BX119983, CT583646

UniProtKB/TrEMBL

A0A8M1PRE2, Q6NSM5

Related

ENSDARP00000072733.5, ENSDART00000078271.6

Conserved Domains (2) summary

cd03865
Location:27 → 349

M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup

cd11308
Location:353 → 425

Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain