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Rfk Riboflavin kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40936, updated on 10-May-2024

Summary

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Official Symbol
Rfkprovided by FlyBase
Official Full Name
Riboflavin kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0014930
Locus tag
Dmel_CG2846
See related
AllianceGenome:FB:FBgn0014930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-84Ea; C; CG2846; Dmel\CG2846
Summary
Predicted to enable riboflavin kinase activity. Predicted to be involved in FMN biosynthetic process and riboflavin metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human RFK (riboflavin kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Rfk in Genome Data Viewer
Location:
84E5-84E5; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7912017..7913290, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3737739..3739012, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ER membrane protein complex subunit 1 Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase Neighboring gene kipferl Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis. Penney J, et al. J Mol Evol, 2008 May. PMID 18392760
  2. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham CH, et al. Genes Dev, 1991 Oct. PMID 1916263
  3. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Clark DV. Genetics, 1994 Feb. PMID 8150282, Free PMC Article
  4. A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Baker BS, et al. Genes Dev, 1988 Apr. PMID 2453394
  5. Repetitive arrays containing a housekeeping gene have altered polytene chromosome morphology in Drosophila. Clark DV, et al. Chromosoma, 1998 May. PMID 9601978

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables riboflavin kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables riboflavin kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in FMN biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in FMN biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
riboflavin kinase
Names
CG2846-PA
CG2846-PB
Rfk-PA
Rfk-PB
transcript C
NP_001287218.1
NP_649749.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7912017..7913290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141492.3 → NP_649749.2  riboflavin kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649749.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6IDS5, O76206, Q95S97
    UniProtKB/TrEMBL
    A0A0B4LHX1
    Related
    FBpp0081260
    Conserved Domains (1) summary
    pfam01687
    Location:6 → 131
    Flavokinase; Riboflavin kinase

  2. NM_001300289.1 → NP_001287218.1  riboflavin kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287218.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6IDS5, O76206, Q95S97
    UniProtKB/TrEMBL
    A0A0B4LHX1
    Conserved Domains (1) summary
    pfam01687
    Location:6 → 131
    Flavokinase; Riboflavin kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHX1 A0A0B4LHX1
O76206.1 O76206

Gene LinkOut

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