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Alg12 Alg12 alpha-1,6-mannosyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41191, updated on 11-Apr-2024

Summary

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Official Symbol
Alg12provided by FlyBase
Official Full Name
Alg12 alpha-1,6-mannosyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0037743
Locus tag
Dmel_CG8412
See related
AllianceGenome:FB:FBgn0037743
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8412; dAlg12; Dmel\CG8412
Summary
Predicted to enable alpha-1,6-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
85E6-85E6; 3-49 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9756491..9759313)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5582213..5585035)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Protein phosphatase D3 Neighboring gene Telo2 interacting protein 1 Neighboring gene Regulatory particle triple-A ATPase 3-related Neighboring gene Mannose phosphate isomerase Neighboring gene Synaptosomal-associated protein 24kDa

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The essential Smp3 protein is required for addition of the side-branching fourth mannose during assembly of yeast glycosylphosphatidylinositols. Grimme SJ, et al. J Biol Chem, 2001 Jul 20. PMID 11356840
  2. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article
  3. Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin. Park SY, et al. Genetics, 2014 Feb. PMID 24281154, Free PMC Article
  4. Diversity and functions of protein glycosylation in insects. Walski T, et al. Insect Biochem Mol Biol, 2017 Apr. PMID 28232040
  5. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Alg12 alpha-1,6-mannosyltransferase
Names
Alg12-PA
CG8412-PA
NP_649939.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9756491..9759313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141682.4 → NP_649939.1  Alg12 alpha-1,6-mannosyltransferase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VH78
    Related
    FBpp0081608
    Conserved Domains (1) summary
    cl21590
    Location:3 → 351
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VH78.1 Q9VH78

Gene LinkOut

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