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MAPT microtubule associated protein tau [ Homo sapiens (human) ]

Gene ID: 4137, updated on 5-Dec-2021

Summary

Official Symbol
MAPTprovided by HGNC
Official Full Name
microtubule associated protein tauprovided by HGNC
Primary source
HGNC:HGNC:6893
See related
Ensembl:ENSG00000186868 MIM:157140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103
Summary
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues See more
Orthologs
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Genomic context

See MAPT in Genome Data Viewer
Location:
17q21.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (45894538..46028334)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43971920..44105700)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LINC02210-CRHR1 readthrough Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene MAPT antisense RNA 1 Neighboring gene signal peptide peptidase like 2C Neighboring gene uncharacterized LOC105371800 Neighboring gene MAPT intronic transcript 1 Neighboring gene saitohin Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene uncharacterized LOC107985027 Neighboring gene KANSL1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
GeneReviews: Not available
Common variants at 12q15 and 12q24 are associated with infant head circumference.
GeneReviews: Not available
Common variants at 6q22 and 17q21 are associated with intracranial volume.
GeneReviews: Not available
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.
GeneReviews: Not available
Frontotemporal dementia
MedGen: C0338451 OMIM: 600274 GeneReviews: Not available
Compare labs
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
GeneReviews: Not available
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
GeneReviews: Not available
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.
GeneReviews: Not available
Genome-wide association study reveals genetic risk underlying Parkinson's disease.
GeneReviews: Not available
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes.
GeneReviews: Not available
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
GeneReviews: Not available
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
GeneReviews: Not available
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.
GeneReviews: Not available
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
GeneReviews: Not available
Parkinson disease, late-onset
MedGen: C3160718 OMIM: 168600 GeneReviews: Parkinson Disease Overview
Compare labs
Parkinson-dementia syndrome
MedGen: C1850077 OMIM: 260540 GeneReviews: Not available
Compare labs
Pick disease
MedGen: C0236642 OMIM: 172700 GeneReviews: Not available
Compare labs
Supranuclear palsy, progressive, 1
MedGen: C4551863 OMIM: 601104 GeneReviews: Not available
Compare labs
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
GeneReviews: Not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-05-08)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-05-08)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat increases cellular amounts of phosphorylated MAPT (Tau); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine PubMed
tat HIV-1 Tat induces hyperphosphorylation of Tau PubMed
tat HIV-1 Tat induces hyperphosphorylation of Tau in neuronal cells PubMed
tat Treatment of microglia cells with HIV-1 Tat shows TAU5 and synapsin-1 positive inclusions in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31424, MGC138549

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding TAS
Traceable Author Statement
more info
PubMed 
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin binding TAS
Traceable Author Statement
more info
PubMed 
enables apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables double-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables dynactin binding TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables histone-dependent DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables lipoprotein particle binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microtubule binding NAS
Non-traceable Author Statement
more info
PubMed 
enables microtubule binding TAS
Traceable Author Statement
more info
PubMed 
enables microtubule lateral binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables minor groove of adenine-thymine-rich DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol binding TAS
Traceable Author Statement
more info
PubMed 
enables phosphatidylinositol bisphosphate binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein phosphatase 2A binding TAS
Traceable Author Statement
more info
PubMed 
enables protein-macromolecule adaptor activity TAS
Traceable Author Statement
more info
PubMed 
enables sequence-specific DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables single-stranded DNA binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in astrocyte activation TAS
Traceable Author Statement
more info
PubMed 
involved_in axon development TAS
Traceable Author Statement
more info
PubMed 
involved_in axonal transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in axonal transport TAS
Traceable Author Statement
more info
PubMed 
involved_in axonal transport of mitochondrion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to brain-derived neurotrophic factor stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to heat TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to reactive oxygen species TAS
Traceable Author Statement
more info
PubMed 
involved_in central nervous system neuron development TAS
Traceable Author Statement
more info
PubMed 
involved_in cytoplasmic microtubule organization TAS
Traceable Author Statement
more info
PubMed 
involved_in generation of neurons NAS
Non-traceable Author Statement
more info
PubMed 
involved_in internal protein amino acid acetylation TAS
Traceable Author Statement
more info
PubMed 
involved_in intracellular distribution of mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microglial cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microtubule cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of establishment of protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tubulin deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of tubulin deacetylation TAS
Traceable Author Statement
more info
PubMed 
involved_in neurofibrillary tangle assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development TAS
Traceable Author Statement
more info
PubMed 
involved_in plus-end-directed organelle transport along microtubule TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of diacylglycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA metabolic process TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of chromosome organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of long-term synaptic depression TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule polymerization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule polymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of microtubule polymerization or depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial fission IC
Inferred by Curator
more info
PubMed 
involved_in regulation of response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
involved_in response to lead ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in stress granule assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in supramolecular fiber organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in supramolecular fiber organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon NAS
Non-traceable Author Statement
more info
PubMed 
located_in axon TAS
Traceable Author Statement
more info
PubMed 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
located_in glial cell projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in main axon ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in neurofibrillary tangle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neurofibrillary tangle NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in somatodendritic compartment IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in somatodendritic compartment TAS
Traceable Author Statement
more info
PubMed 
part_of tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein tau
Names
G protein beta1/gamma2 subunit-interacting factor 1
PHF-tau
neurofibrillary tangle protein
paired helical filament-tau
protein phosphatase 1, regulatory subunit 103

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007398.2 RefSeqGene

    Range
    5092..138872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_660

mRNA and Protein(s)

  1. NM_001123066.4NP_001116538.2  microtubule-associated protein tau isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) encodes the longest isoform (6).
    Source sequence(s)
    AW295014, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS45715.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000410838.2, ENST00000415613.6
    Conserved Domains (1) summary
    pfam00418
    Location:610639
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. NM_001123067.4NP_001116539.1  microtubule-associated protein tau isoform 5

    See identical proteins and their annotated locations for NP_001116539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (5) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS45716.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000505258.1, ENST00000680542.1
    Conserved Domains (2) summary
    pfam00418
    Location:246275
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    cl28033
    Location:27233
    Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
  3. NM_001203251.2NP_001190180.1  microtubule-associated protein tau isoform 7

    See identical proteins and their annotated locations for NP_001190180.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (7) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, CR936218, DN996935
    UniProtKB/TrEMBL
    A0A024RA19, B3KTM0
    Related
    ENSP00000443028.2, ENST00000535772.6
    Conserved Domains (1) summary
    pfam00418
    Location:246275
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. NM_001203252.2NP_001190181.1  microtubule-associated protein tau isoform 8

    See identical proteins and their annotated locations for NP_001190181.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (8) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    AK095802, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS56033.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    B3KTM0
    Related
    ENSP00000389250.3, ENST00000431008.7
    Conserved Domains (1) summary
    pfam00418
    Location:275305
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. NM_001377265.1NP_001364194.1  microtubule-associated protein tau isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC217771, CR936218
    Related
    ENSP00000262410.6, ENST00000262410.10
    Conserved Domains (2) summary
    PHA03247
    Location:217645
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:667696
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. NM_001377266.1NP_001364195.1  microtubule-associated protein tau isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC217771, CR936218
    Related
    ENSP00000340820.6, ENST00000344290.10
    Conserved Domains (2) summary
    PHA03247
    Location:217564
    PHA03247; large tegument protein UL36; Provisional
    pfam00418
    Location:601631
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. NM_001377267.1NP_001364196.1  microtubule-associated protein tau isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC217771, CR936218
    Conserved Domains (2) summary
    PHA03307
    Location:27233
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00418
    Location:223245
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. NM_001377268.1NP_001364197.1  microtubule-associated protein tau isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC217771, CR936218
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  9. NM_005910.6NP_005901.2  microtubule-associated protein tau isoform 2

    See identical proteins and their annotated locations for NP_005901.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6.
    Source sequence(s)
    BN000503, CR936218, DN996935, X14474
    Consensus CDS
    CCDS11499.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024RA17
    Related
    ENSP00000303214.7, ENST00000351559.10
    Conserved Domains (1) summary
    pfam00418
    Location:275304
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  10. NM_016834.5NP_058518.1  microtubule-associated protein tau isoform 3

    See identical proteins and their annotated locations for NP_058518.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks five internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (3) has identical N- and C-termini but lacks four segments, as compared to isoform 6.
    Source sequence(s)
    BC114948, CR936218, DN996935
    Consensus CDS
    CCDS11500.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024R9Y0
    Related
    ENSP00000408975.3, ENST00000446361.7
    Conserved Domains (1) summary
    pfam00418
    Location:217246
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  11. NM_016835.5NP_058519.3  microtubule-associated protein tau isoform 1

    See identical proteins and their annotated locations for NP_058519.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks one internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (1) has identical N- and C-termini but lacks one segment, as compared to isoform 6.
    Source sequence(s)
    AW295014, BC114948, BN000503, CR936218, DN996935
    Consensus CDS
    CCDS11501.1
    UniProtKB/Swiss-Prot
    P10636
    UniProtKB/TrEMBL
    A0A024R9Y1
    Related
    ENSP00000458742.1, ENST00000571987.5
    Conserved Domains (1) summary
    pfam00418
    Location:592621
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  12. NM_016841.5NP_058525.1  microtubule-associated protein tau isoform 4

    See identical proteins and their annotated locations for NP_058525.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks six internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (4) has identical N- and C-termini but lacks five segments, as compared to isoform 6.
    Source sequence(s)
    BC000558, CR936218, DN996935
    Consensus CDS
    CCDS11502.1
    UniProtKB/Swiss-Prot
    P10636
    Related
    ENSP00000334886.8, ENST00000334239.12
    Conserved Domains (1) summary
    pfam00418
    Location:217247
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RNA

  1. NR_165166.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC217771, CR936218

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    45894538..46028334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257370.4XP_005257427.1  microtubule-associated protein tau isoform X8

    Conserved Domains (1) summary
    pfam00418
    Location:312341
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  2. XM_005257366.3XP_005257423.1  microtubule-associated protein tau isoform X4

    Conserved Domains (1) summary
    pfam00418
    Location:638667
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  3. XM_005257362.4XP_005257419.1  microtubule-associated protein tau isoform X1

    Conserved Domains (1) summary
    pfam00418
    Location:696725
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  4. XM_005257365.4XP_005257422.1  microtubule-associated protein tau isoform X3

    Conserved Domains (1) summary
    pfam00418
    Location:696725
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  5. XM_005257367.4XP_005257424.1  microtubule-associated protein tau isoform X5

    Conserved Domains (1) summary
    pfam00418
    Location:630659
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  6. XM_005257368.4XP_005257425.1  microtubule-associated protein tau isoform X6

    Conserved Domains (1) summary
    pfam00418
    Location:630659
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  7. XM_005257369.4XP_005257426.1  microtubule-associated protein tau isoform X7

    Conserved Domains (1) summary
    pfam00418
    Location:341370
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_005257371.4XP_005257428.1  microtubule-associated protein tau isoform X9

    Conserved Domains (1) summary
    pfam00418
    Location:283312
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    760287..893665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    596685..730446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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