MAPT microtubule associated protein tau [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAPTprovided by HGNC
Official Full Name: microtubule associated protein tauprovided by HGNC
Primary source: HGNC:HGNC:6893
See related: Ensembl:ENSG00000186868 MIM:157140; AllianceGenome:HGNC:6893
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6
Summary: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 70.2), kidney (RPKM 12.0) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (45894554..46028334)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (46756177..46889953)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (43971920..44105700)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1beta and BDNF.
Title: Tau Accumulation in the Spinal Cord Contributes to Chronic Inflammatory Pain by Upregulation of IL-1β and BDNF.
Influence of FTDP-17 mutants on circular tau RNAs.
Title: Influence of FTDP-17 mutants on circular tau RNAs.
Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects.
Title: Plasma Phosphorylated Tau 231 Increases at One-Year Intervals in Cognitively Unimpaired Subjects.
Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles.
Title: Complexes of tubulin oligomers and tau form a viscoelastic intervening network cross-bridging microtubules into bundles.
Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons.
Title: Behavioral and Neurophysiological Implications of Pathological Human Tau Expression in Serotonin Neurons.
Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
Title: Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement.
Title: Activation of transient receptor potential vanilloid 1 ameliorates tau accumulation-induced synaptic damage and cognitive dysfunction via autophagy enhancement.
P2X7R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Title: P2X(7)R influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes.
Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review.
Title: Dissecting the Clinical Heterogeneity and Genotype-Phenotype Correlations of MAPT Mutations: A Systematic Review.
Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.
Title: Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (1812)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Frontotemporal dementia MedGen: C0338451 OMIM: 600274 GeneReviews: Not available	Compare labs
Parkinson disease, late-onset MedGen: C3160718 OMIM: 168600 GeneReviews: Parkinson Disease Overview, Gaucher Disease	Compare labs
Pick disease MedGen: C0236642 OMIM: 172700 GeneReviews: Not available	Compare labs
Progressive supranuclear palsy-parkinsonism syndrome MedGen: C1850077 OMIM: 260540 GeneReviews: Not available	Compare labs
Supranuclear palsy, progressive, 1 MedGen: C4551863 OMIM: 601104 GeneReviews: MAPT-Related Frontotemporal Dementia	Compare labs

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2012-05-08) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2012-05-08) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at 12q15 and 12q24 are associated with infant head circumference. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common variants at 6q22 and 17q21 are associated with intracranial volume. EBI GWAS Catalog EBI GWAS CatalogPubMed
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals genetic risk underlying Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of a novel Parkinson's disease locus via stratified genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. EBI GWAS Catalog EBI GWAS CatalogPubMed
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat increases cellular amounts of phosphorylated MAPT (Tau); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine	PubMed
	tat	HIV-1 Tat induces hyperphosphorylation of Tau	PubMed
	tat	HIV-1 Tat induces hyperphosphorylation of Tau in neuronal cells	PubMed
	tat	Treatment of microglia cells with HIV-1 Tat shows TAU5 and synapsin-1 positive inclusions in cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S2046 (e-PCR)
- UniSTS:64777

RH11914 (e-PCR)
- UniSTS:2878

Mapt (e-PCR), detects polymorphism
- UniSTS:465482

PMC23724P1 (e-PCR)
- UniSTS:272207

STS-H17335 (e-PCR)
- UniSTS:50017

D17S1383E (e-PCR)
- UniSTS:46725

WI-16913 (e-PCR)
- UniSTS:61835

G19745 (e-PCR)
- UniSTS:17825

A001X18 (e-PCR)
- UniSTS:17826

RH47296 (e-PCR)
- UniSTS:24995

G32838 (e-PCR)
- UniSTS:117417

A007F48 (e-PCR)
- UniSTS:17083

RH44969 (e-PCR)
- UniSTS:18126

D17S1451E (e-PCR)
- UniSTS:150491

RH17756 (e-PCR)
- UniSTS:36829

A009U15 (e-PCR)
- UniSTS:26345

RH121608 (e-PCR)
- UniSTS:134380

G63048 (e-PCR)
- UniSTS:140023

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	TAS Traceable Author Statement more info	PubMed
enables apolipoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables dynactin binding	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone-dependent DNA binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipoprotein particle binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables microtubule binding	NAS Non-traceable Author Statement more info	PubMed
enables microtubule binding	TAS Traceable Author Statement more info	PubMed
enables microtubule lateral binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables minor groove of adenine-thymine-rich DNA binding	TAS Traceable Author Statement more info	PubMed
enables phosphatidylinositol binding	TAS Traceable Author Statement more info	PubMed
enables phosphatidylinositol bisphosphate binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein phosphatase 2A binding	TAS Traceable Author Statement more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	TAS Traceable Author Statement more info	PubMed
enables sequence-specific DNA binding	TAS Traceable Author Statement more info	PubMed
enables single-stranded DNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in amyloid fibril formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte activation	TAS Traceable Author Statement more info	PubMed
involved_in axon development	TAS Traceable Author Statement more info	PubMed
involved_in axonal transport	NAS Non-traceable Author Statement more info	PubMed
involved_in axonal transport	TAS Traceable Author Statement more info	PubMed
involved_in axonal transport of mitochondrion	TAS Traceable Author Statement more info	PubMed
involved_in cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to brain-derived neurotrophic factor stimulus	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to heat	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to nerve growth factor stimulus	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to reactive oxygen species	TAS Traceable Author Statement more info	PubMed
involved_in central nervous system neuron development	TAS Traceable Author Statement more info	PubMed
involved_in cytoplasmic microtubule organization	TAS Traceable Author Statement more info	PubMed
involved_in generation of neurons	NAS Non-traceable Author Statement more info	PubMed
involved_in internal protein amino acid acetylation	TAS Traceable Author Statement more info	PubMed
involved_in intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	TAS Traceable Author Statement more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule cytoskeleton organization	NAS Non-traceable Author Statement more info	PubMed
involved_in microtubule polymerization	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of establishment of protein localization to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitochondrial membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of tubulin deacetylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of tubulin deacetylation	TAS Traceable Author Statement more info	PubMed
involved_in neurofibrillary tangle assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection development	TAS Traceable Author Statement more info	PubMed
involved_in plus-end-directed organelle transport along microtubule	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of diacylglycerol kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of microtubule polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromosome organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of long-term synaptic depression	TAS Traceable Author Statement more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of microtubule polymerization	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of microtubule polymerization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of microtubule polymerization or depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial fission	IC Inferred by Curator more info	PubMed
involved_in regulation of synaptic plasticity	TAS Traceable Author Statement more info	PubMed
involved_in response to lead ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress granule assembly	TAS Traceable Author Statement more info	PubMed
involved_in supramolecular fiber organization	IDA Inferred from Direct Assay more info	PubMed
involved_in supramolecular fiber organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	NAS Non-traceable Author Statement more info	PubMed
located_in axon	TAS Traceable Author Statement more info	PubMed
located_in axon cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic ribonucleoprotein granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	TAS Traceable Author Statement more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in main axon	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	NAS Non-traceable Author Statement more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in neurofibrillary tangle	IDA Inferred from Direct Assay more info	PubMed
located_in neurofibrillary tangle	NAS Non-traceable Author Statement more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in somatodendritic compartment	IMP Inferred from Mutant Phenotype more info	PubMed
located_in somatodendritic compartment	TAS Traceable Author Statement more info	PubMed
part_of tubulin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: microtubule-associated protein tau

Names: G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; Tau-derived paired helical filament hexapeptide; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007398.2 RefSeqGene

Range

5092..138872

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_660

mRNA and Protein(s)

NM_001123066.4 → NP_001116538.2 microtubule-associated protein tau isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) encodes the longest isoform (6).

Source sequence(s)

AW295014, BN000503, CR936218, DN996935

Consensus CDS

CCDS45715.1

UniProtKB/TrEMBL

A0A0G2JMX7

Related

ENSP00000410838.2, ENST00000415613.6

Conserved Domains (1) summary

pfam00418
Location:610 → 639

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001123067.4 → NP_001116539.1 microtubule-associated protein tau isoform 5

See identical proteins and their annotated locations for NP_001116539.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (5) has identical N- and C-termini but lacks four segments, as compared to isoform 6.

Source sequence(s)

BC114948, CR936218, DN996935

Consensus CDS

CCDS45716.1

UniProtKB/TrEMBL

A0A7P0T936

Related

ENSP00000413056.2, ENST00000420682.7

Conserved Domains (2) summary

PHA03307
Location:27 → 233

PHA03307; transcriptional regulator ICP4; Provisional

pfam00418
Location:246 → 275

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001203251.2 → NP_001190180.1 microtubule-associated protein tau isoform 7

See identical proteins and their annotated locations for NP_001190180.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks four internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (7) has identical N- and C-termini but lacks four segments, as compared to isoform 6.

Source sequence(s)

AK095802, CR936218, DN996935

Consensus CDS

CCDS92347.1

UniProtKB/TrEMBL

A0A7P0T936, I3L170

Related

ENSP00000443028.2, ENST00000535772.6

Conserved Domains (1) summary

pfam00418
Location:246 → 275

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001203252.2 → NP_001190181.1 microtubule-associated protein tau isoform 8

See identical proteins and their annotated locations for NP_001190181.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (8) has identical N- and C-termini but lacks three segments, as compared to isoform 6.

Source sequence(s)

AK095802, BN000503, CR936218, DN996935

Consensus CDS

CCDS56033.1

UniProtKB/TrEMBL

A0A7P0T936

Related

ENSP00000389250.3, ENST00000431008.7

Conserved Domains (1) summary

pfam00418
Location:275 → 305

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001377265.1 → NP_001364194.1 microtubule-associated protein tau isoform 9

Status: REVIEWED

Source sequence(s)

AC217771, CR936218

Consensus CDS

CCDS92345.1

UniProtKB/TrEMBL

A0A0G2JPD5, A0A7I2PJZ2

Related

ENSP00000262410.6, ENST00000262410.10

Conserved Domains (2) summary

PHA03247
Location:217 → 645

PHA03247; large tegument protein UL36; Provisional

pfam00418
Location:667 → 696

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001377266.1 → NP_001364195.1 microtubule-associated protein tau isoform 10

Status: REVIEWED

Source sequence(s)

AC217771, CR936218

Consensus CDS

CCDS92346.1

UniProtKB/TrEMBL

A0A0G2JPD5, A0A7I2PLE3

Related

ENSP00000340820.6, ENST00000344290.10

Conserved Domains (2) summary

PHA03247
Location:217 → 564

PHA03247; large tegument protein UL36; Provisional

pfam00418
Location:601 → 631

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001377267.1 → NP_001364196.1 microtubule-associated protein tau isoform 11

Status: REVIEWED

Source sequence(s)

AC217771, CR936218

Conserved Domains (2) summary

PHA03307
Location:27 → 233

PHA03307; transcriptional regulator ICP4; Provisional

pfam00418
Location:223 → 245

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_001377268.1 → NP_001364197.1 microtubule-associated protein tau isoform 4

Status: REVIEWED

Source sequence(s)

AC217771, CR936218

Consensus CDS

CCDS11502.1

UniProtKB/TrEMBL

I3L170

Conserved Domains (1) summary

pfam00418
Location:217 → 247

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_005910.6 → NP_005901.2 microtubule-associated protein tau isoform 2

See identical proteins and their annotated locations for NP_005901.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks three internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (2) has identical N- and C-termini but lacks three segments, as compared to isoform 6.

Source sequence(s)

BN000503, CR936218, DN996935, X14474

Consensus CDS

CCDS11499.1

UniProtKB/TrEMBL

A0A7P0T936

Related

ENSP00000303214.7, ENST00000351559.10

Conserved Domains (1) summary

pfam00418
Location:275 → 304

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_016834.5 → NP_058518.1 microtubule-associated protein tau isoform 3

See identical proteins and their annotated locations for NP_058518.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks five internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (3) has identical N- and C-termini but lacks four segments, as compared to isoform 6.

Source sequence(s)

BC114948, CR936218, DN996935

Consensus CDS

CCDS11500.1

UniProtKB/TrEMBL

A0A7P0T936

Related

ENSP00000408975.3, ENST00000446361.7

Conserved Domains (1) summary

pfam00418
Location:217 → 246

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_016835.5 → NP_058519.3 microtubule-associated protein tau isoform 1

See identical proteins and their annotated locations for NP_058519.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks one internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (1) has identical N- and C-termini but lacks one segment, as compared to isoform 6.

Source sequence(s)

AW295014, BC114948, BN000503, CR936218, DN996935

Consensus CDS

CCDS11501.1

UniProtKB/Swiss-Prot

P10636, P18518, Q14799, Q15549, Q15550, Q15551, Q1RMF6, Q53YB1, Q5CZI7, Q5XWF0, Q6QT54, Q9UDJ3, Q9UMH0, Q9UQ96

UniProtKB/TrEMBL

A0A0G2JPD5

Related

ENSP00000458742.1, ENST00000571987.5

Conserved Domains (1) summary

pfam00418
Location:592 → 621

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
NM_016841.5 → NP_058525.1 microtubule-associated protein tau isoform 4

See identical proteins and their annotated locations for NP_058525.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks six internal coding exons, as compared to variant 6. The reading frame is not affected, and the resulting isoform (4) has identical N- and C-termini but lacks five segments, as compared to isoform 6.

Source sequence(s)

BC000558, CR936218, DN996935

Consensus CDS

CCDS11502.1

UniProtKB/TrEMBL

I3L170

Related

ENSP00000334886.8, ENST00000334239.12

Conserved Domains (1) summary

pfam00418
Location:217 → 247

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat

RNA

NR_165166.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC217771, CR936218

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

45894554..46028334

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005257362.5 → XP_005257419.1 microtubule-associated protein tau isoform X1

UniProtKB/TrEMBL

A0A0G2JPD5

Conserved Domains (1) summary

pfam00418
Location:696 → 725

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_005257365.5 → XP_005257422.1 microtubule-associated protein tau isoform X2

UniProtKB/TrEMBL

A0A0G2JPD5

Conserved Domains (1) summary

pfam00418
Location:696 → 725

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_005257367.5 → XP_005257424.1 microtubule-associated protein tau isoform X5

UniProtKB/TrEMBL

A0A0G2JPD5

Conserved Domains (1) summary

pfam00418
Location:630 → 659

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_005257368.5 → XP_005257425.1 microtubule-associated protein tau isoform X8

UniProtKB/TrEMBL

A0A0G2JPD5

Conserved Domains (1) summary

pfam00418
Location:630 → 659

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_005257369.5 → XP_005257426.1 microtubule-associated protein tau isoform X11

Conserved Domains (1) summary

pfam00418
Location:341 → 370

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_047436079.1 → XP_047292035.1 microtubule-associated protein tau isoform X13
XM_047436074.1 → XP_047292030.1 microtubule-associated protein tau isoform X4
XM_047436076.1 → XP_047292032.1 microtubule-associated protein tau isoform X7
XM_005257370.5 → XP_005257427.1 microtubule-associated protein tau isoform X12

UniProtKB/TrEMBL

A0A7P0T936

Conserved Domains (1) summary

pfam00418
Location:312 → 341

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_047436080.1 → XP_047292036.1 microtubule-associated protein tau isoform X15
XM_005257366.4 → XP_005257423.1 microtubule-associated protein tau isoform X3

UniProtKB/TrEMBL

A0A0G2JPD5

Conserved Domains (1) summary

pfam00418
Location:638 → 667

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_047436075.1 → XP_047292031.1 microtubule-associated protein tau isoform X6
XM_047436077.1 → XP_047292033.1 microtubule-associated protein tau isoform X9
XM_047436078.1 → XP_047292034.1 microtubule-associated protein tau isoform X10
XM_005257371.5 → XP_005257428.1 microtubule-associated protein tau isoform X14

UniProtKB/TrEMBL

A0A7P0T936

Conserved Domains (1) summary

pfam00418
Location:283 → 312

Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
XM_047436081.1 → XP_047292037.1 microtubule-associated protein tau isoform X16