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Fer3 48 related 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41411, updated on 10-May-2024

Summary

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Official Symbol
Fer3provided by FlyBase
Official Full Name
48 related 3provided by FlyBase
Primary source
FLYBASE:FBgn0037937
Locus tag
Dmel_CG6913
See related
AllianceGenome:FB:FBgn0037937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD04689; bHLHa32; CG6913; Dmel\CG6913; Dnato3; nato3
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in embryonic brain; embryonic procephalic segment; larval ventral nerve cord; presumptive embryonic/larval central nervous system; and ventral nerve cord primordium. Orthologous to human FERD3L (Fer3 like bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Fer3 in Genome Data Viewer
Location:
86E16-86E16; 3-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11693410..11694311, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7519132..7520033, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila. Seroka A, et al. Dev Biol, 2022 Sep. PMID 35660371, Free PMC Article
  2. Mining gene expression data for pollutants (dioxin, toluene, formaldehyde) and low dose of gamma-irradiation. Moskalev A, et al. PLoS One, 2014. PMID 24475070, Free PMC Article
  3. N-twist, an evolutionarily conserved bHLH protein expressed in the developing CNS, functions as a transcriptional inhibitor. Verzi MP, et al. Dev Biol, 2002 Sep 1. PMID 12217327
  4. Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse. Segev E, et al. Mech Dev, 2001 Aug. PMID 11472856
  5. A genomewide survey of basic helix-loop-helix factors in Drosophila. Moore AW, et al. Proc Natl Acad Sci U S A, 2000 Sep 12. PMID 10973473, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification and genomic structure of Nato3 in fly, mouse and man. Nervous system expression detected in fly and mouse.
    Title: Nato3 is an evolutionarily conserved bHLH transcription factor expressed in the CNS of Drosophila and mouse.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in developmental process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
48 related 3
Names
CG6913-PA
Fer3-PA
N-twist
nephew of atonal 3
ntwist

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11693410..11694311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079598.3 → NP_524322.1  48 related 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524322.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0AQE5, Q9VGJ5
    UniProtKB/TrEMBL
    C0MK08, C0MK09
    Related
    FBpp0081911
    Conserved Domains (1) summary
    pfam00010
    Location:87 → 135
    HLH; Helix-loop-helix DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGJ5.2 Q9VGJ5

Gene LinkOut

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