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C10orf55 chromosome 10 putative open reading frame 55 [ Homo sapiens (human) ]

Gene ID: 414236, updated on 5-Mar-2024

Summary

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Official Symbol
C10orf55provided by HGNC
Official Full Name
chromosome 10 putative open reading frame 55provided by HGNC
Primary source
HGNC:HGNC:31008
See related
Ensembl:ENSG00000222047 AllianceGenome:HGNC:31008
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables identical protein binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 3.9), urinary bladder (RPKM 3.4) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
10q22.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73909969..73922777, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74781360..74794168, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75669727..75682535, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr10:75574449-75574702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579102-75579602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75579603-75580103 Neighboring gene MPRA-validated peak1013 silencer Neighboring gene calcium/calmodulin dependent protein kinase II gamma Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75617818-75618318 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75618319-75618819 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2493 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3579 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3580 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75646944-75648143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75648172-75649130 Neighboring gene uncharacterized LOC124902454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:75668366-75669565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2495 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:75672789-75673988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75679930-75680578 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:75680579-75681225 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:75691709-75692908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3584 Neighboring gene plasminogen activator, urokinase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:75716666-75717173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3586 Neighboring gene Sharpr-MPRA regulatory region 4338 Neighboring gene VISTA enhancer hs2142 Neighboring gene Sharpr-MPRA regulatory region 295 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2661 Neighboring gene CRISPRi-validated cis-regulatory element chr10.2662 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:75758175-75758826 Neighboring gene Sharpr-MPRA regulatory region 4496 Neighboring gene uncharacterized LOC124902455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3588 Neighboring gene vinculin Neighboring gene uncharacterized LOC124902458

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes. Hayward CP, et al. PLoS One, 2017. PMID 28301587, Free PMC Article
  2. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Jostins L, et al. Nature, 2012 Nov 1. PMID 23128233, Free PMC Article
  3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. Bennett EJ, et al. Cell, 2010 Dec 10. PMID 21145461, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. QPD and control megakaryocytes contained minimal reads for C10orf55, and C10orf55 protein was not increased in QPD megakaryocytes or platelets
    Title: The duplication mutation of Quebec platelet disorder dysregulates PLAU, but not C10orf55, selectively increasing production of normal PLAU transcripts by megakaryocytes but not granulocytes.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Other Names

  • uncharacterized protein C10orf55

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_160937.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI912900, AK092517, BC049374, DB019640

  2. NR_160938.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI912900, AK092517, BC049374
    Related
    ENST00000409178.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73909969..73922777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74781360..74794168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001791.2: Suppressed sequence

    Description
    NM_001001791.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SWW7.1 GenPept UniProtKB/Swiss-Prot:Q5SWW7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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