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MFGE8 milk fat globule EGF and factor V/VIII domain containing [ Gallus gallus (chicken) ]

Gene ID: 415494, updated on 5-Mar-2024

Summary

Symbol
MFGE8provided by CGNC
Full Name
milk fat globule EGF and factor V/VIII domain containingprovided by CGNC
Primary source
CGNC:5060
See related
Ensembl:ENSGALG00010020155
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
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Genomic context

See MFGE8 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (13046524..13053821)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (12924289..12931564)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene retinaldehyde binding protein 1 Neighboring gene abhydrolase domain containing 2 Neighboring gene hyaluronan and proteoglycan link protein 3 Neighboring gene aggrecan

Genomic regions, transcripts, and products

General protein information

Preferred Names
lactadherin
Names
milk fat globule-EGF factor 8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277110.2NP_001264039.1  lactadherin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    E1C0K5
    Related
    ENSGALP00010028762.1, ENSGALT00010048678.1
    Conserved Domains (4) summary
    smart00231
    Location:314472
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:109144
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:317471
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00008
    Location:69105
    EGF; EGF-like domain
  2. NM_001277111.2NP_001264040.1  lactadherin isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    JAENSK010000245
    Conserved Domains (4) summary
    smart00231
    Location:308466
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00054
    Location:109144
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:311465
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    pfam00008
    Location:69105
    EGF; EGF-like domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    13046524..13053821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12924289..12931564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)