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Spn88Eb Serpin 88Eb [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41829, updated on 10-May-2024

Summary

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Official Symbol
Spn88Ebprovided by FlyBase
Official Full Name
Serpin 88Ebprovided by FlyBase
Primary source
FLYBASE:FBgn0038299
Locus tag
Dmel_CG6687
See related
AllianceGenome:FB:FBgn0038299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6687; Dmel\CG6687; serpin; Spn88EB
Summary
Involved in epithelium regeneration and regulation of stem cell division. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); lung disease (multiple); and thrombophilia (multiple). Orthologous to several human genes including SERPINB1 (serpin family B member 1); SERPINC1 (serpin family C member 1); and SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Spn88Eb in Genome Data Viewer
Location:
88E3-88E3; 3-56 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15206703..15208762, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11032425..11034484, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea Neighboring gene Mau2 sister chromatid cohesion factor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Shal Interactor of Di-Leucine Motif

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The serpin Spn5 is essential for wing expansion in Drosophila melanogaster. Charron Y, et al. Int J Dev Biol, 2008. PMID 18956323
  2. A serpin from the parasitoid wasp Leptopilina boulardi targets the Drosophila phenoloxidase cascade. Colinet D, et al. Dev Comp Immunol, 2009 May. PMID 19109990
  3. The neuropeptide Drosulfakinin regulates social isolation-induced aggression in Drosophila. Agrawal P, et al. J Exp Biol, 2020 Jan 29. PMID 31900346, Free PMC Article
  4. The Drosophila serpins: multiple functions in immunity and morphogenesis. Reichhart JM, et al. Methods Enzymol, 2011. PMID 21683256
  5. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in epithelium regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to fungus HEP PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
serpin 88Eb
Names
CG6687-PA
Dm-serpin-88Eb
Spn88Eb-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15206703..15208762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142170.3 → NP_650427.1  serpin 88Eb [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650427.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4VA01, Q9VFC1
    Related
    FBpp0082594
    Conserved Domains (1) summary
    cd00172
    Location:37 → 418
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFC1 Q9VFC1

Gene LinkOut

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