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Set [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41844, updated on 10-May-2024

Summary

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Official Symbol
Setprovided by FlyBase
Primary source
FLYBASE:FBgn0014879
Locus tag
Dmel_CG4299
See related
AllianceGenome:FB:FBgn0014879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4299; Dmel\CG4299; dSet; dSET; SET; TAF-Ibeta
Summary
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; germ layer; presumptive embryonic/larval central nervous system; and ventral ectoderm anlage. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability; gonadal dysgenesis; and sudden infant death syndrome. Orthologous to several human genes including SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Set in Genome Data Viewer
Location:
88E8-88E8; 3-56 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15263552..15265253)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11089274..11090975)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene Suppressor of variegation 3-9 Neighboring gene ATP synthase, oligomycin sensitivity conferring protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene Centrosomal protein 190kD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ. Kim DW, et al. Biochem Biophys Res Commun, 2010 Sep 24. PMID 20800572
  2. Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity. Kim JY, et al. Nucleic Acids Res, 2012 Jan. PMID 21911363, Free PMC Article
  3. Members of the NAP/SET family of proteins interact specifically with B-type cyclins. Kellogg DR, et al. J Cell Biol, 1995 Aug. PMID 7622566, Free PMC Article
  4. A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo. Ng T, et al. Dev Genes Evol, 2006 May. PMID 16506071
  5. The Drosophila SET domain encoding gene dEset is essential for proper development. Stabell M, et al. Hereditas, 2006 Dec. PMID 17362353

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A homologue of the vertebrate SET domain regulates terminal differentiation of the tracheal system in the Drosophila embryo.
    Title: A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
  2. By using spatio-temporal RNA interference we show that dEset is required at several stages of development coinciding with ecdysone pulses, possibly as a repressor of transcription of target genes
    Title: The Drosophila SET domain encoding gene dEset is essential for proper development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Set
Names
CG4299-PA
Set-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15263552..15265253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142181.3 → NP_650438.2  Set [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650438.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53997, Q540W9, Q9VFA5
    Related
    FBpp0082521
    Conserved Domains (1) summary
    pfam00956
    Location:31 → 227
    NAP; Nucleosome assembly protein (NAP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53997.2 P53997

Gene LinkOut

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