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Cp190 Centrosomal protein 190kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41848, updated on 26-Apr-2024

Summary

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Official Symbol
Cp190provided by FlyBase
Official Full Name
Centrosomal protein 190kDprovided by FlyBase
Primary source
FLYBASE:FBgn0000283
Locus tag
Dmel_CG6384
See related
AllianceGenome:FB:FBgn0000283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AbS1-4; Bx-63; Bx63; Cen185; Cen190; CEN190; CG6384; CP-190; CP-60; cp190; CP190; CP190_DROME; DMAP 190; DMAP-190; dmap190; Dmap190; DMAP190; Dmel\CG6384; E(mod)4-1; Map190; Rb188
Summary
Enables several functions, including POZ domain binding activity; chromatin insulator sequence binding activity; and protein homodimerization activity. Involved in several processes, including chromatin organization; nuclear axial expansion; and regulation of transcription, DNA-templated. Located in chromosome; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including adult head; embryonic brain; extended germ band embryo; and larval ventral nerve cord. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
88E9-88E11; 3-56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15270432..15275241, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11096154..11100963, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Set Neighboring gene ATP synthase, oligomycin sensitivity conferring protein Neighboring gene uncharacterized protein Neighboring gene Zinc/iron regulated transporter-related protein 88E Neighboring gene antisense RNA:CR46081 Neighboring gene uncharacterized protein Neighboring gene MORF-related gene 15 Neighboring gene lethal (3) neo43

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster. Fedotova AA, et al. Dokl Biochem Biophys, 2023 Apr. PMID 37340291
  2. [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline]. Romanov SE, et al. Mol Biol (Mosk), 2023 Jan-Feb. PMID 36976746
  3. Analysis of Chromatin Interactions Mediated by Specific Architectural Proteins in Drosophila Cells. Ando-Kuri M, et al. Methods Mol Biol, 2018. PMID 29605857, Free PMC Article
  4. Newly Characterized Region of CP190 Associates with Microtubules and Mediates Proper Spindle Morphology in Drosophila Stem Cells. Plevock KM, et al. PLoS One, 2015. PMID 26649574, Free PMC Article
  5. Functional sub-division of the Drosophila genome via chromatin looping: the emerging importance of CP190. Ahanger SH, et al. Nucleus, 2013 Mar-Apr. PMID 23333867, Free PMC Article

See all (337) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The N-Terminal Part of Drosophila CP190 Is a Platform for Interaction with Multiple Architectural Proteins.
    Title: The N-Terminal Part of Drosophila CP190 Is a Platform for Interaction with Multiple Architectural Proteins.
  2. The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
    Title: The MADF-BESS Protein CP60 Is Recruited to Insulators via CP190 and Has Redundant Functions in Drosophila.
  3. Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.
    Title: Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.
  4. [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline].
    Title: [Insulator Protein CP190 Regulates Expression of Spermatocyte Differentiation Genes in Drosophila melanogaster Male Germline].
  5. CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.
    Title: CTCF, BEAF-32, and CP190 are not required for the establishment of TADs in early Drosophila embryos but have locus-specific roles.
  6. Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.
    Title: Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements.
  7. Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
    Title: Mechanism and functional role of the interaction between CP190 and the architectural protein Pita in Drosophila melanogaster.
  8. Human CTCF Interacts with Drosophila CP190, but not with Kaiso.
    Title: Human CTCF Interacts with Drosophila CP190, but not with Kaiso.
  9. M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
    Title: M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
  10. HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
    Title: HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables POZ domain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin insulator sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterochromatin boundary formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear axial expansion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle microtubule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein 190kD
Names
CG6384-PA
CG6384-PB
Cp190-PA
Cp190-PB
E(mod)4-1
centrosomal protein 190
centrosomal protein 190 kD
centrosomal protein 190 kDa
centrosomal protein 90
centrosomal protein of 190 kDa
enhancer of mod(mdg4)4-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15270432..15275241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079635.3 → NP_524359.2  centrosomal protein 190kD, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524359.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Y3, Q24478, Q9VFA1
    Related
    FBpp0082580
    Conserved Domains (3) summary
    smart00225
    Location:31 → 127
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:540 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 122
    BTB; BTB/POZ domain

  2. NM_169632.2 → NP_731998.1  centrosomal protein 190kD, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731998.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V2Y3, Q24478, Q9VFA1
    Related
    FBpp0082581
    Conserved Domains (3) summary
    smart00225
    Location:31 → 127
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00020
    Location:540 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20 → 122
    BTB; BTB/POZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24478.2 Q24478

Gene LinkOut

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