Atg4b Autophagy-related 4b [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg4bprovided by FlyBase
Official Full Name: Autophagy-related 4bprovided by FlyBase
Primary source: FLYBASE:FBgn0038325
Locus tag: Dmel_CG6194
See related: AllianceGenome:FB:FBgn0038325
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: APG4; atg4; Atg4; ATG4; atg4b; AUT2; CG6194; DmAtg4-like; Dmel\CG6194
Summary: Predicted to enable Atg8-specific protease activity. Predicted to be involved in autophagy. Predicted to be located in cytosol. Is expressed in several structures, including embryonic brain; extended germ band embryo; larval ventral nerve cord; and salivary gland. Orthologous to human ATG4C (autophagy related 4C cysteine peptidase) and ATG4D (autophagy related 4D cysteine peptidase). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15353720..15356924, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11179442..11182646, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Atg4b Overexpression Extends Lifespan and Healthspan in Drosophila melanogaster.
Title: Atg4b Overexpression Extends Lifespan and Healthspan in Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-phosphatidylethanolamide deconjugating activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-phosphatidylethanolamide deconjugating activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in C-terminal protein lipidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in aggrephagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein delipidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info