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Uros2 Uroporphyrinogen III synthase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41908, updated on 10-May-2024

Summary

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Official Symbol
Uros2provided by FlyBase
Official Full Name
Uroporphyrinogen III synthase 2provided by FlyBase
Primary source
FLYBASE:FBgn0038361
Locus tag
Dmel_CG9589
See related
AllianceGenome:FB:FBgn0038361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT11468; CG9589; Dmel\CG9589
Summary
Predicted to enable uroporphyrinogen-III synthase activity. Predicted to be involved in heme biosynthetic process and uroporphyrinogen III biosynthetic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Uros2 in Genome Data Viewer
Location:
89A5-89A5; 3-58 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15788521..15789494)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11614243..11615216)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene crossover suppressor on 3 of Gowen Neighboring gene Acylphosphatase 2 Neighboring gene non-specific lethal 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. c(3)G encodes a Drosophila synaptonemal complex protein. Page SL, et al. Genes Dev, 2001 Dec 1. PMID 11731477, Free PMC Article
  2. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
  3. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article
  4. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article
  5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables uroporphyrinogen-III synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uroporphyrinogen-III synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in uroporphyrinogen III biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uroporphyrinogen III biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uroporphyrinogen III synthase 2
Names
CG9589-PA
Uros2-PA
NP_650489.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15788521..15789494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142232.2 → NP_650489.1  uroporphyrinogen III synthase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650489.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VF38
    Related
    FBpp0082627
    Conserved Domains (1) summary
    cd06578
    Location:9 → 251
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MZD2 Q8MZD2
Q9VF38 Q9VF38

Gene LinkOut

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