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IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 [ Gallus gallus (chicken) ]

Gene ID: 420617, updated on 3-Apr-2024

Summary

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Symbol
IGF2BP3provided by CGNC
Full Name
insulin like growth factor 2 mRNA binding protein 3provided by CGNC
Primary source
CGNC:51304
See related
Ensembl:ENSGALG00010001476
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
VICKZ3
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (31057514..31164938, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (31103377..31210878, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene glycoprotein nmb Neighboring gene mitochondrial assembly of ribosomal large subunit 1 Neighboring gene transformer 2 alpha homolog Neighboring gene coiled-coil domain containing 126

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway. Yin H, et al. Int J Mol Sci, 2020 Feb 28. PMID 32121275, Free PMC Article
  2. Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens. Rengaraj D, et al. Asian-Australas J Anim Sci, 2017 Jul. PMID 28111433, Free PMC Article
  3. VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins. Yisraeli JK. Biol Cell, 2005 Jan. PMID 15601260
  4. Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap. Galan JA, et al. J Am Soc Mass Spectrom, 2011 Feb. PMID 21472591, Free PMC Article
  5. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway.
    Title: miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway.
  2. Real-time qPCR results revealed that the downregulation of chicken miRNA gga-let-7d in the intestinal mucosal layer of Necrotic enteritis induced Fayoumi chicken line M15.2 was associated with the upregulation of its top-ranking target gene IGF2BP3.
    Title: Distribution and differential expression of microRNAs in the intestinal mucosal layer of necrotic enteritis induced Fayoumi chickens.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
insulin-like growth factor 2 mRNA-binding protein 3
Names
IGF-II mRNA-binding protein 3
IGF2 mRNA-binding protein 3
IMP-3
VICKZ family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006359.1 → NP_001006359.1  insulin-like growth factor 2 mRNA-binding protein 3

    See identical proteins and their annotated locations for NP_001006359.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ719686
    UniProtKB/Swiss-Prot
    Q5ZLP8
    UniProtKB/TrEMBL
    A0A8V0X5N3
    Related
    ENSGALP00010001853.1, ENSGALT00010003410.1
    Conserved Domains (3) summary
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cl00098
    Location:276 → 370
    KH-I; K homology (KH) RNA-binding domain, type I

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    31057514..31164938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015281444.4 → XP_015136930.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZLP8
    UniProtKB/TrEMBL
    A0A8V0X5N3
    Related
    ENSGALP00010001856.1, ENSGALT00010003413.1
    Conserved Domains (3) summary
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cl00098
    Location:276 → 370
    KH-I; K homology (KH) RNA-binding domain, type I

  2. XM_025147195.3 → XP_025002963.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZLP8
    UniProtKB/TrEMBL
    A0A8V0X5N3
    Related
    ENSGALP00010001858.1, ENSGALT00010003415.1
    Conserved Domains (3) summary
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 (RRM1) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 (RRM2) found in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cl00098
    Location:276 → 370
    KH-I; K homology (KH) RNA-binding domain, type I

  3. XM_025147196.3 → XP_025002964.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V0X5N3
    Conserved Domains (4) summary
    cd00105
    Location:280 → 345
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd12627
    Location:1 → 77
    RRM1_IGF2BP3; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    cd12630
    Location:81 → 156
    RRM2_IGF2BP3; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)
    pfam00013
    Location:367 → 431
    KH_1; KH domain

  4. XM_046922845.1 → XP_046778801.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    31103377..31210878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911132.1 → XP_046767088.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZLP8

  2. XM_046911133.1 → XP_046767089.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5ZLP8

  3. XM_046911134.1 → XP_046767090.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X2

  4. XM_046911135.1 → XP_046767091.1  insulin-like growth factor 2 mRNA-binding protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZLP8.1 GenPept UniProtKB/Swiss-Prot:Q5ZLP8

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