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CG7379 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42140, updated on 4-Apr-2024

Summary

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Official Symbol
CG7379provided by FlyBase
Primary source
FLYBASE:FBgn0038546
Locus tag
Dmel_CG7379
See related
AllianceGenome:FB:FBgn0038546
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7339; Dmel\CG7379; Ing1; ING1
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Part of Sin3-type complex. Is expressed in several structures, including anterior endoderm; embryonic brain; embryonic/larval nervous system; embryonic/larval visceral muscle cell; and extended germ band embryo. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1) and ING2 (inhibitor of growth family member 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
90C5-90C5; 3-61 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17796376..17798304, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13622098..13624026, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene pasiflora 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Nicknack

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. Rusu AD, et al. Open Biol, 2021 Sep. PMID 34493070, Free PMC Article
  2. Systematic Analysis of SIN3 Histone Modifying Complex Components During Development. Barnes VL, et al. Sci Rep, 2018 Nov 19. PMID 30451916, Free PMC Article
  3. Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. Spain MM, et al. J Biol Chem, 2010 Aug 27. PMID 20566628, Free PMC Article
  4. Pasiflora proteins are novel core components of the septate junction. Deligiannaki M, et al. Development, 2015 Sep 1. PMID 26329602, Free PMC Article
  5. The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules. Zhang W, et al. J Mol Biol, 2016 Jul 17. PMID 27117189, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7379-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17796376..17798304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142399.3 → NP_650656.1  uncharacterized protein Dmel_CG7379 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650656.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEF5
    Related
    FBpp0082953
    Conserved Domains (2) summary
    cd15584
    Location:360 → 404
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:17 → 116
    ING; Inhibitor of growth proteins N-terminal histone-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEF5 Q9VEF5

Gene LinkOut

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