Dys Dystrophin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dysprovided by FlyBase
Official Full Name: Dystrophinprovided by FlyBase
Primary source: FLYBASE:FBgn0260003
Locus tag: Dmel_CG34157
See related: AllianceGenome:FB:FBgn0260003
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17750; CG31175; CG34157; CG7240; CG7243; CG7344; det; DLP; DLP1; DLP186; DLP2; DLP3; dmDLP; DmDLP; dmDp186; dmDys; DmDYS; Dmel\CG34157; Dp117; Dp186; Dp205; dys; DYS; GI3046716; IDLP
Summary: Enables WW domain binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; maintenance of presynaptic active zone structure; and modulation of chemical synaptic transmission. Located in cytoplasm; cytoskeleton; and neuromuscular junction. Part of dystrophin-associated glycoprotein complex. Is expressed in several structures, including embryonic/larval gut; embryonic/larval nervous system; extended germ band embryo; muscle system; and presumptive embryonic/larval system. Used to study Duchenne muscular dystrophy and muscular dystrophy. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (dystrophin) and UTRN (utrophin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 92A5-92A10; 3-66 cM

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19461085..19597288)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15286807..15423010)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting functional autophagy.
Title: Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting functional autophagy.
Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
Title: Oriented basement membrane fibrils provide a memory for F-actin planar polarization via the Dystrophin-Dystroglycan complex during tissue elongation.
The evidence has been presented that the highly conserved Cdc42 Rho GTPase plays a key role in the postsynaptic Dystrophin/Dystrobrevin pathway for synaptic homeostasis.
Title: Dystrobrevin is required postsynaptically for homeostatic potentiation at the Drosophila NMJ.
Dys protein regulates tarsal joint formation in response to Notch activity during Drosophila leg development.
Title: The bHLH-PAS transcription factor dysfusion regulates tarsal joint formation in response to Notch activity during drosophila leg development.
The findings suggest that the signaling functions of Dystrophin protein are able to ameliorate dilated cardiomyopathy, and thus might help to improve heart muscle function in micro-Dystrophin-based gene therapy approaches.
Title: Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.
Nrk, mbl, capt and Cam genetically interact with dystrophin and/or dystroglycan in the process of axon path-finding in the eye.
Title: New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye.
only dystroglycan, but not dystrophin deficiency causes myodegeneration induced by energetic stress suggesting that dystroglycan might be a component of the low-energy pathway and act as a transducer of energetic stress in normal and dystrophic muscles
Title: Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components.
Dystrophin and the Rho GTPase crossveinless-c signaling pathway likely interact at the postsynaptic side of the NMJ to maintain synaptic homeostasis.
Title: The RhoGAP crossveinless-c interacts with Dystrophin and is required for synaptic homeostasis at the Drosophila neuromuscular junction.
Possibility that Dp186 modulates other non-Gbb/Wit-dependent retrograde signaling pathways required to maintain normal synaptic physiology.
Title: The dystrophin Dp186 isoform regulates neurotransmitter release at a central synapse in Drosophila.
RNAi-mediated knockdown in the mesoderm shortens lifespan. Deletion of the large isoforms increases the heart rate by widening the cardiac tube and lowering fractional shortening, a phenotype reminiscent of dilated cardiomyopathy
Title: Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of muscle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of presynaptic active zone structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of short-term neuronal synaptic plasticity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in cell cortex	HDA more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
part_of dystrophin-associated glycoprotein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of dystrophin-associated glycoprotein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dystrophin

Names: CG34157-PA; CG34157-PB; CG34157-PC; CG34157-PD; CG34157-PE; CG34157-PF; CG34157-PG; CG34157-PH; CG34157-PI; CG34157-PJ; CG34157-PK; CG34157-PL; Dys-PA; Dys-PB; Dys-PC; Dys-PD; Dys-PE; Dys-PF; Dys-PG; Dys-PH; Dys-PI; Dys-PJ; Dys-PK; Dys-PL; Dystrophin-like protein 1; Dystrophin-like protein 186; Dystrophin-like protein 2; Dystrophin-like protein 3; detached; dystrophin Dp186

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

19461085..19597288

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001043263.2 → NP_001036728.1 dystrophin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036728.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VDW6

Conserved Domains (9) summary

COG0419
Location:420 → 989

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:848 → 1623

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2509 → 2746

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2884 → 2914

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3142 → 3190

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:45 → 143

CH; Calponin homology (CH) domain

pfam09068
Location:2915 → 3029

EF-hand_2; EF hand

pfam09069
Location:3033 → 3132

EF-hand_3; EF-hand

cl02488
Location:1321 → 1517

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001275801.1 → NP_001262730.1 dystrophin, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262730.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHR4

Conserved Domains (10) summary

smart00150
Location:1927 → 2024

SPEC; Spectrin repeats

COG0419
Location:420 → 989

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:848 → 1623

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2139 → 2376

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2531 → 2561

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:2789 → 2837

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:45 → 143

CH; Calponin homology (CH) domain

pfam09068
Location:2562 → 2676

EF-hand_2; EF hand

pfam09069
Location:2680 → 2779

EF-hand_3; EF-hand

cl02488
Location:1321 → 1517

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001275803.1 → NP_001262732.1 dystrophin, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262732.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGH0

Conserved Domains (10) summary

smart00150
Location:1895 → 1992

SPEC; Spectrin repeats

COG0419
Location:388 → 957

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:816 → 1591

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2107 → 2344

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2499 → 2529

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:2757 → 2805

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:13 → 111

CH; Calponin homology (CH) domain

pfam09068
Location:2530 → 2644

EF-hand_2; EF hand

pfam09069
Location:2648 → 2747

EF-hand_3; EF-hand

cl02488
Location:1289 → 1485

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001043259.2 → NP_001036724.1 dystrophin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036724.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VDW6

Conserved Domains (10) summary

smart00150
Location:1895 → 1992

SPEC; Spectrin repeats

COG0419
Location:388 → 957

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:816 → 1591

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2107 → 2344

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2482 → 2512

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:2740 → 2788

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:13 → 111

CH; Calponin homology (CH) domain

pfam09068
Location:2513 → 2627

EF-hand_2; EF hand

pfam09069
Location:2631 → 2730

EF-hand_3; EF-hand

cl02488
Location:1289 → 1485

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001043257.2 → NP_001036722.1 dystrophin, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036722.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KI51, Q0KI52, Q0KI53, Q9BK96, Q9BK98, Q9BKA0, Q9GT71, Q9VDW4, Q9VDW6

Conserved Domains (9) summary

COG0419
Location:325 → 957

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:816 → 1591

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2477 → 2714

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2852 → 2882

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3110 → 3158

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:13 → 111

CH; Calponin homology (CH) domain

pfam09068
Location:2883 → 2997

EF-hand_2; EF hand

pfam09069
Location:3001 → 3100

EF-hand_3; EF-hand

cl02488
Location:1289 → 1485

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001043258.2 → NP_001036723.1 dystrophin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036723.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VDW6

Conserved Domains (9) summary

COG0419
Location:388 → 957

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:816 → 1591

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2477 → 2714

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2852 → 2882

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3110 → 3158

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:13 → 111

CH; Calponin homology (CH) domain

pfam09068
Location:2883 → 2997

EF-hand_2; EF hand

pfam09069
Location:3001 → 3100

EF-hand_3; EF-hand

cl02488
Location:1289 → 1485

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001043261.2 → NP_001036726.1 dystrophin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036726.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VDW6

Conserved Domains (9) summary

COG0419
Location:395 → 964

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:823 → 1598

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2484 → 2721

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2859 → 2889

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3117 → 3165

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam00307
Location:20 → 118

CH; Calponin homology (CH) domain

pfam09068
Location:2890 → 3004

EF-hand_2; EF hand

pfam09069
Location:3008 → 3107

EF-hand_3; EF-hand

cl02488
Location:1296 → 1492

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001275804.1 → NP_001262733.1 dystrophin, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262733.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGB9

Conserved Domains (8) summary

smart00150
Location:74 → 171

SPEC; Spectrin repeats

cd00176
Location:286 → 523

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:678 → 708

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:936 → 984

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:709 → 823

EF-hand_2; EF hand

pfam09069
Location:827 → 926

EF-hand_3; EF-hand

cl02488
Location:542 → 652

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02600
Location:1177 → 1213

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
NM_001043256.2 → NP_001036721.1 dystrophin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036721.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O62529, Q9BK99, Q9VDW3

Conserved Domains (7) summary

cd00176
Location:649 → 886

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:1024 → 1054

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:1282 → 1330

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:1055 → 1169

EF-hand_2; EF hand

pfam09069
Location:1173 → 1272

EF-hand_3; EF-hand

cl02488
Location:888 → 998

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02600
Location:1523 → 1559

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
NM_001043260.2 → NP_001036725.1 dystrophin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036725.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0KI50, Q2VQZ5, Q6IJP4

Conserved Domains (8) summary

cd00176
Location:870 → 1071

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:1209 → 1239

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:1467 → 1515

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:1240 → 1354

EF-hand_2; EF hand

pfam09069
Location:1358 → 1457

EF-hand_3; EF-hand

pfam11740
Location:1598 → 1669

KfrA_N; Plasmid replication region DNA-binding N-term

cl02488
Location:1073 → 1183

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02600
Location:1708 → 1744

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
NM_001043262.2 → NP_001036727.1 dystrophin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036727.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7YU29

Conserved Domains (7) summary

cd00201
Location:406 → 436

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:664 → 712

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:437 → 551

EF-hand_2; EF hand

pfam09069
Location:555 → 654

EF-hand_3; EF-hand

pfam11740
Location:795 → 866

KfrA_N; Plasmid replication region DNA-binding N-term

cl02488
Location:270 → 380

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02600
Location:905 → 941

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
NM_001275802.1 → NP_001262731.1 dystrophin, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262731.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHE2

Conserved Domains (7) summary

cd00201
Location:406 → 436

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:664 → 712

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:437 → 551

EF-hand_2; EF hand

pfam09069
Location:555 → 654

EF-hand_3; EF-hand

pfam11740
Location:795 → 866

KfrA_N; Plasmid replication region DNA-binding N-term

cl02488
Location:270 → 380

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl02600
Location:905 → 941

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A0A0B4KGB9		A0A0B4KGB9
A0A0B4KGH0		A0A0B4KGH0
A0A0B4KHE2		A0A0B4KHE2
A0A0B4KHR4		A0A0B4KHR4
Q0KI50.1		Q0KI50
Q7YU29.1		Q7YU29
Q9VDW3.3		Q9VDW3
Q9VDW6.3		Q9VDW6