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Dys Dystrophin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42327, updated on 24-Nov-2022

Summary

Official Symbol
Dysprovided by FlyBase
Official Full Name
Dystrophinprovided by FlyBase
Primary source
FLYBASE:FBgn0260003
Locus tag
Dmel_CG34157
See related
AllianceGenome:FB:FBgn0260003
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17750; CG31175; CG34157; CG7240; CG7243; CG7344; det; DLP; DLP1; DLP186; DLP2; DLP3; dmDLP; DmDLP; dmDp186; dmDys; DmDYS; Dmel\CG34157; Dp117; Dp186; Dp205; dys; DYS; GI3046716; IDLP
Summary
Enables WW domain binding activity. Involved in several processes, including imaginal disc-derived wing morphogenesis; maintenance of presynaptic active zone structure; and modulation of chemical synaptic transmission. Located in cytoplasm; cytoskeleton; and neuromuscular junction. Part of dystrophin-associated glycoprotein complex. Is expressed in several structures, including embryonic/larval gut; embryonic/larval nervous system; extended germ band embryo; muscle system; and presumptive embryonic/larval system. Used to study Duchenne muscular dystrophy and muscular dystrophy. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (dystrophin) and UTRN (utrophin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Dys in Genome Data Viewer
Location:
92A5-92A10; 3-66 cM
Exon count:
46
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19461085..19597288)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15286807..15423010)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Succinyl-coenzyme A synthetase alpha subunit 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Cuticular protein 92A Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables WW domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of muscle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell cortex HDA PubMed 
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
part_of dystrophin-associated glycoprotein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of dystrophin-associated glycoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dystrophin
Names
CG34157-PA
CG34157-PB
CG34157-PC
CG34157-PD
CG34157-PE
CG34157-PF
CG34157-PG
CG34157-PH
CG34157-PI
CG34157-PJ
CG34157-PK
CG34157-PL
Dys-PA
Dys-PB
Dys-PC
Dys-PD
Dys-PE
Dys-PF
Dys-PG
Dys-PH
Dys-PI
Dys-PJ
Dys-PK
Dys-PL
Dystrophin-like protein 1
Dystrophin-like protein 186
Dystrophin-like protein 2
Dystrophin-like protein 3
detached
dystrophin Dp186

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19461085..19597288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043263.2NP_001036728.1  dystrophin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036728.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDW6
    Related
    FBpp0110217, FBtr0110917
    Conserved Domains (9) summary
    COG0419
    Location:420989
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8481623
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:25092746
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:28842914
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:31423190
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:45143
    CH; Calponin homology (CH) domain
    pfam09068
    Location:29153029
    EF-hand_2; EF hand
    pfam09069
    Location:30333132
    EF-hand_3; EF-hand
    cl02488
    Location:13211517
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_001275801.1NP_001262730.1  dystrophin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262730.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHR4
    Related
    FBpp0306629, FBtr0334562
    Conserved Domains (10) summary
    smart00150
    Location:19272024
    SPEC; Spectrin repeats
    COG0419
    Location:420989
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8481623
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:21392376
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:25312561
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:27892837
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:45143
    CH; Calponin homology (CH) domain
    pfam09068
    Location:25622676
    EF-hand_2; EF hand
    pfam09069
    Location:26802779
    EF-hand_3; EF-hand
    cl02488
    Location:13211517
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. NM_001275803.1NP_001262732.1  dystrophin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGH0
    Related
    FBpp0306631, FBtr0334564
    Conserved Domains (10) summary
    smart00150
    Location:18951992
    SPEC; Spectrin repeats
    COG0419
    Location:388957
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8161591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:21072344
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:24992529
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:27572805
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:13111
    CH; Calponin homology (CH) domain
    pfam09068
    Location:25302644
    EF-hand_2; EF hand
    pfam09069
    Location:26482747
    EF-hand_3; EF-hand
    cl02488
    Location:12891485
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  4. NM_001043259.2NP_001036724.1  dystrophin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDW6
    Related
    FBpp0083179, FBtr0083765
    Conserved Domains (10) summary
    smart00150
    Location:18951992
    SPEC; Spectrin repeats
    COG0419
    Location:388957
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8161591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:21072344
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:24822512
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:27402788
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:13111
    CH; Calponin homology (CH) domain
    pfam09068
    Location:25132627
    EF-hand_2; EF hand
    pfam09069
    Location:26312730
    EF-hand_3; EF-hand
    cl02488
    Location:12891485
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  5. NM_001043257.2NP_001036722.1  dystrophin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDW4, Q9VDW6
    Related
    FBpp0110219, FBtr0110919
    Conserved Domains (9) summary
    COG0419
    Location:325957
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8161591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:24772714
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:28522882
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:31103158
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:13111
    CH; Calponin homology (CH) domain
    pfam09068
    Location:28832997
    EF-hand_2; EF hand
    pfam09069
    Location:30013100
    EF-hand_3; EF-hand
    cl02488
    Location:12891485
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  6. NM_001043258.2NP_001036723.1  dystrophin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036723.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDW6
    Related
    FBpp0083178, FBtr0083764
    Conserved Domains (9) summary
    COG0419
    Location:388957
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8161591
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:24772714
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:28522882
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:31103158
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:13111
    CH; Calponin homology (CH) domain
    pfam09068
    Location:28832997
    EF-hand_2; EF hand
    pfam09069
    Location:30013100
    EF-hand_3; EF-hand
    cl02488
    Location:12891485
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  7. NM_001043261.2NP_001036726.1  dystrophin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VDW6
    Related
    FBpp0110218, FBtr0110918
    Conserved Domains (9) summary
    COG0419
    Location:395964
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG1196
    Location:8231598
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00176
    Location:24842721
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:28592889
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:31173165
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam00307
    Location:20118
    CH; Calponin homology (CH) domain
    pfam09068
    Location:28903004
    EF-hand_2; EF hand
    pfam09069
    Location:30083107
    EF-hand_3; EF-hand
    cl02488
    Location:12961492
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  8. NM_001275804.1NP_001262733.1  dystrophin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262733.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGB9
    Related
    FBpp0306632, FBtr0334565
    Conserved Domains (8) summary
    smart00150
    Location:74171
    SPEC; Spectrin repeats
    cd00176
    Location:286523
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:678708
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:936984
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:709823
    EF-hand_2; EF hand
    pfam09069
    Location:827926
    EF-hand_3; EF-hand
    cl02488
    Location:542652
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02600
    Location:11771213
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
  9. NM_001043256.2NP_001036721.1  dystrophin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9BK99, Q9VDW3
    Related
    FBpp0083180, FBtr0083766
    Conserved Domains (7) summary
    cd00176
    Location:649886
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:10241054
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:12821330
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:10551169
    EF-hand_2; EF hand
    pfam09069
    Location:11731272
    EF-hand_3; EF-hand
    cl02488
    Location:888998
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02600
    Location:15231559
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
  10. NM_001043260.2NP_001036725.1  dystrophin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036725.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0KI50, Q6IJP4
    Related
    FBpp0110215, FBtr0110915
    Conserved Domains (8) summary
    cd00176
    Location:8701071
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cd00201
    Location:12091239
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:14671515
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:12401354
    EF-hand_2; EF hand
    pfam09069
    Location:13581457
    EF-hand_3; EF-hand
    pfam11740
    Location:15981669
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02488
    Location:10731183
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02600
    Location:17081744
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
  11. NM_001043262.2NP_001036727.1  dystrophin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036727.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7YU29
    Related
    FBpp0110216, FBtr0110916
    Conserved Domains (7) summary
    cd00201
    Location:406436
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:664712
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:437551
    EF-hand_2; EF hand
    pfam09069
    Location:555654
    EF-hand_3; EF-hand
    pfam11740
    Location:795866
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02488
    Location:270380
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02600
    Location:905941
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
  12. NM_001275802.1NP_001262731.1  dystrophin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262731.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHE2
    Related
    FBpp0306630, FBtr0334563
    Conserved Domains (7) summary
    cd00201
    Location:406436
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd02334
    Location:664712
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:437551
    EF-hand_2; EF hand
    pfam09069
    Location:555654
    EF-hand_3; EF-hand
    pfam11740
    Location:795866
    KfrA_N; Plasmid replication region DNA-binding N-term
    cl02488
    Location:270380
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl02600
    Location:905941
    HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily