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Mrp5 Multidrug resistance protein 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42362, updated on 4-Apr-2024

Summary

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Official Symbol
Mrp5provided by FlyBase
Official Full Name
Multidrug resistance protein 5provided by FlyBase
Primary source
FLYBASE:FBgn0038740
Locus tag
Dmel_CG4562
See related
AllianceGenome:FB:FBgn0038740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4562; CT14766; DmCG4562; Dmel\CG4562; Dme_CG4562; dMRP5
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be integral component of membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including alcoholic pancreatitis; allergic bronchopulmonary aspergillosis; bronchial disease (multiple); congenital bilateral absence of vas deferens (multiple); and lung disease (multiple). Orthologous to several human genes including ABCC4 (ATP binding cassette subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
92B4-92B4; 3-67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19865417..19875678, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15691139..15701400, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Mitochondrial calcium uptake 3 Neighboring gene Inositol-requiring enzyme-1 Neighboring gene Mitochondrial rRNA methyltransferase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Activator-recruited cofactor subunit 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insecticide detoxification indicator strains as tools for enhancing chemical discovery screens. Shah S, et al. Pest Manag Sci, 2012 Jan. PMID 21681918
  2. The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family. Tarnay JN, et al. Insect Mol Biol, 2004 Oct. PMID 15373810
  3. Combgap contributes to recruitment of Polycomb group proteins in Drosophila. Ray P, et al. Proc Natl Acad Sci U S A, 2016 Apr 5. PMID 27001825, Free PMC Article
  4. Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. Mayer F, et al. J Neurosci, 2009 Mar 18. PMID 19295159, Free PMC Article
  5. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type heme transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heme export IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
multidrug resistance protein 5
Names
CG4562-PA
CG4562-PB
CG4562-PC
CG4562-PD
CG4562-PE
Mrp5-PA
Mrp5-PB
Mrp5-PC
Mrp5-PD
Mrp5-PE
NP_001097841.1
NP_001262745.1
NP_001262746.1
NP_001262747.1
NP_650838.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    19865417..19875678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275816.1 → NP_001262745.1  multidrug resistance protein 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDT3
    Conserved Domains (4) summary
    cd03244
    Location:1074 → 1295
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:443 → 643
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1300
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:799 → 1027
    ABC_membrane; ABC transporter transmembrane region

  2. NM_142581.2 → NP_650838.1  multidrug resistance protein 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VDT3
    Related
    FBpp0083268
    Conserved Domains (4) summary
    cd03244
    Location:1074 → 1295
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:443 → 643
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1300
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:799 → 1027
    ABC_membrane; ABC transporter transmembrane region

  3. NM_001275818.1 → NP_001262747.1  multidrug resistance protein 5, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGI0
    Conserved Domains (4) summary
    cd03244
    Location:1074 → 1295
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:443 → 643
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1300
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:799 → 1027
    ABC_membrane; ABC transporter transmembrane region

  4. NM_001275817.1 → NP_001262746.1  multidrug resistance protein 5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI72
    Conserved Domains (3) summary
    cd03250
    Location:443 → 643
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:92 → 663
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl00549
    Location:98 → 367
    ABC_membrane; ABC transporter transmembrane region

  5. NM_001104371.2 → NP_001097841.1  multidrug resistance protein 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5BI72
    Conserved Domains (3) summary
    cd03250
    Location:443 → 643
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    COG1132
    Location:92 → 663
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    cl00549
    Location:98 → 367
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGI0 A0A0B4KGI0
Q5BI72 Q5BI72
Q9VDT3 Q9VDT3

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