BF2 major histocompatibility complex B, class I heavy chain BF2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: BF2provided by CGNC
Official Full Name: major histocompatibility complex B, class I heavy chain BF2provided by CGNC
Primary source: CGNC:52441
See related: Ensembl:ENSGALG00010003817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: BF; B-F; B12; BF12; BFIV; BFa1; B-FIV; B-LB2; BFIV21; B-F-S01; B-F-S02; B-F-S03; B-F-S09; B-F-S11; B-F-S12; B-F-S13; B-F-S14
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Genomic context

Location:: chromosome: 16

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	16	NC_052547.1 (2226703..2229465, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	16	NC_052588.1 (1127833..1130595, complement)

Chromosome 16 - NC_052547.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BF2 restricts the antigen specific cytotoxic T lymphocytes immune response to avian leukosis virus.
Title: Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs.
The results demonstrated the tumour incidence was highly related with the alternative exon 7 splice variant of the BF gene (P < 0.05).
Title: The relationship between the alternative exon 7 splice variant of the BF gene and MHC-related Marek's disease resistance in chickens.
Two three-dimensional structures of the chicken MHC class I molecule BF2*2101 were determined by X-ray crystallography.
Title: Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
five new BF2 groups and a new beta(2)m group exist in the three Chinese chicken lines
Title: Characterization of BF2 and beta2m in three Chinese chicken lines.
The two-dimensional (2D) and three-dimensional (3D) structures of chicken major histocompatibility complex (MHC) class I protein (BF2 and beta2m)were elucidated.
Title: Structures and homology modeling of chicken major histocompatibility complex protein class I (BF2 and beta2m).

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Major histocompatibility complex class I antigen BF2; major histocompatibility complex class I antigen BF2

Names: B-F histocompatibility F10 antigen; B-F major; B-F-beta-IV; F10 alpha chain; MHC BF2 class I; MHC class I alpha chain 1; MHC class I alpha chain 2; MHC class I antigen B-F heavy chain; MHC class I antigen B-F major heavy chain; MHC class I molecule; MHC class1 antigen; alpha chain 2; class I histocompatibility antigen, F10 alpha chain; major histocompatibility complex class I glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031338.2 → NP_001026509.1 Major histocompatibility complex class I antigen BF2 isoform 1 precursor

See identical proteins and their annotated locations for NP_001026509.1

Status: VALIDATED

Source sequence(s)

JAENSK010000283

UniProtKB/TrEMBL

A0A089FKD3, Q8SPC7, Q95601

Conserved Domains (3) summary

cd07698
Location:201 → 292

IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain

smart00410
Location:216 → 279

IG_like; Immunoglobulin like

pfam00129
Location:22 → 197

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
NM_001397292.1 → NP_001384221.1 Major histocompatibility complex class I antigen BF2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000283

UniProtKB/TrEMBL

A0A089FJ51, A0A089FKX6, A0A089GLF7, F1CN12

Related

ENSGALP00010005186.1, ENSGALT00010008842.1

Conserved Domains (2) summary

pfam00129
Location:22 → 197

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cd21029
Location:201 → 291

IgC1_CD1; Immunoglobulin domain of Cluster of Differentiation (CD) 1; member of the C1-set of Ig superfamily (IgSF) domains
NM_001397293.1 → NP_001384222.1 Major histocompatibility complex class I antigen BF2 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000283

Conserved Domains (1) summary

smart00407
Location:129 → 198

IGc1; Immunoglobulin C-Type

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052547.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2226703..2229465 complement

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GenBank, FASTA, Sequence Viewer (Graphics)