InR Insulin-like receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: InRprovided by FlyBase
Official Full Name: Insulin-like receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0283499
Locus tag: Dmel_CG18402
See related: AllianceGenome:FB:FBgn0283499
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 18402; CG18402; DIHR; DILR; dinr; dinR; dInr; dInR; dINR; DInr; DInR; dInsR; dINSR; dir; dIR; DIR; Dir-a; Dir-b; DIRbeta; dIRH; DIRH; Dmel\CG18402; er10; Igfr1; inr; inR; Inr; INR; Inr-alpha; Inr-beta; INS; InsR; insulin/insulin-like growth factor receptor; IR; l(3)05545; l(3)93Dj; l(3)er10; lnR; RTK; sprout
Summary: Enables insulin binding activity and insulin-activated receptor activity. Involved in several processes, including gamete generation; lipid homeostasis; and positive regulation of cell development. Is integral component of plasma membrane. Part of insulin receptor complex. Is expressed in several structures, including central nervous system; corpus allatum; gastrula embryo; gut section; and posterior midgut primordium. Used to study alcohol dependence; high grade glioma; sleep disorder; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); diabetes mellitus (multiple); kidney cancer (multiple); liver disease (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 93E4-93E9; 3-72 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21570248..21619321, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17395970..17445043, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.
Title: Long-range repression by ecdysone receptor on complex enhancers of the insulin receptor gene.
The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.
Title: The insulin receptor regulates the persistence of mechanical nociceptive sensitization in flies and mice.
Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.
Title: Aging Regulated Through a Stability Model of Insulin/Insulin Growth Factor Receptor Function.
Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.
Title: Aging modulated by the Drosophila insulin receptor through distinct structure-defined mechanisms.
Lar physically associates with InR and serves as a negative regulator for insulin signaling in the Drosophila larval hematopoietic niche.
Title: Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche.
The authors reveal that transient activation of JNK enhances the expression of the insulin receptor and initiates the insulin-Myc signaling loop to promote mitochondrial respiration and biogenesis by boosting the expression of electron transport chain subunits and of factors essential for mtDNA replication and expression, and for the import of mitochondrial proteins.
Title: Electron transport chain biogenesis activated by a JNK-insulin-Myc relay primes mitochondrial inheritance in Drosophila.
Rab6 promotes localization of the insulin receptor to the plasma membrane.
Title: Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Hsp83 functions upstream of the InR/PI3K/Akt pathway during neural stem cell reactivation.
Title: Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation.
Immunosenescence in Drosophila suggests its possible mechanisms that involve changes in insulin/IGF-1 signaling. (Review)
Title: Unraveling the Molecular Mechanism of Immunosenescence in Drosophila.
a sensory neuron-specific function of InR regulates the persistence of injury-associated hypersensitivity.
Title: Drosophila Insulin receptor regulates the persistence of injury-induced nociceptive sensitization.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1882 (e-PCR)
- UniSTS:75941

Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c21610044-21609899 mobile_element_type = transposon:NOF{}1401

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables insulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables insulin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol 3-kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic development via the syncytial blastoderm	IEP Inferred from Expression Pattern more info	PubMed
involved_in female germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-band shortening	IGI Inferred from Genetic Interaction more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germ-line stem cell asymmetric division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptide hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	HMP more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary spermatocyte growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to anoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cocaine	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Insulin-like receptor

Names: CG18402-PA; CG18402-PB; CG18402-PC; CG18402-PD; Igf-1 receptor; InR-PA; InR-PB; InR-PC; InR-PD; Insulin-receptor; drosophila insulin receptor; insulin; insulin receptor; insulin receptor homolog; insulin receptor homologue; insulin-like receptor; insulin-like receptor tyrosine kinase; insulin/IGF receptor; lethal(3)93Dj; sprout

NP_001138093.1

EC 2.7.10.1

NP_001138094.1

EC 2.7.10.1

NP_001138095.1

EC 2.7.10.1

NP_524436.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21570248..21619321 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144621.3 → NP_001138093.1 Insulin-like receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138093.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7Z0N6, P09208, Q24023, Q24089, Q9VD94

UniProtKB/TrEMBL

A0A7T4WRU1

Conserved Domains (6) summary

cd05032
Location:1364 → 1652

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:1224 → 1302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:545 → 592

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:512 → 645

Furin-like; Furin-like cysteine rich region

pfam01030
Location:356 → 465

Recep_L_domain; Receptor L domain

pfam07714
Location:1371 → 1650

Pkinase_Tyr; Protein tyrosine kinase
NM_079712.6 → NP_524436.2 Insulin-like receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524436.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B7Z0N6, P09208, Q24023, Q24089, Q9VD94

UniProtKB/TrEMBL

A0A7T4WRU1

Related

FBpp0083519

Conserved Domains (6) summary

cd05032
Location:1364 → 1652

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:1224 → 1302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:545 → 592

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:512 → 645

Furin-like; Furin-like cysteine rich region

pfam01030
Location:356 → 465

Recep_L_domain; Receptor L domain

pfam07714
Location:1371 → 1650

Pkinase_Tyr; Protein tyrosine kinase
NM_001144622.2 → NP_001138094.1 Insulin-like receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138094.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7Z0N6, P09208, Q24023, Q24089, Q9VD94

UniProtKB/TrEMBL

A0A7T4WRU1

Conserved Domains (6) summary

cd05032
Location:1364 → 1652

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:1224 → 1302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:545 → 592

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:512 → 645

Furin-like; Furin-like cysteine rich region

pfam01030
Location:356 → 465

Recep_L_domain; Receptor L domain

pfam07714
Location:1371 → 1650

Pkinase_Tyr; Protein tyrosine kinase
NM_001144623.2 → NP_001138095.1 Insulin-like receptor, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138095.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B7Z0N6, P09208, Q24023, Q24089, Q9VD94

UniProtKB/TrEMBL

A0A7T4WRU1

Conserved Domains (6) summary

cd05032
Location:1364 → 1652

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:1224 → 1302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:545 → 592

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:512 → 645

Furin-like; Furin-like cysteine rich region

pfam01030
Location:356 → 465

Recep_L_domain; Receptor L domain

pfam07714
Location:1371 → 1650

Pkinase_Tyr; Protein tyrosine kinase