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CG5849 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42556, updated on 10-May-2024

Summary

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Official Symbol
CG5849provided by FlyBase
Primary source
FLYBASE:FBgn0038897
Locus tag
Dmel_CG5849
See related
AllianceGenome:FB:FBgn0038897
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5849
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; gnathal primordium; spermatozoon; and stomatogastric nervous system. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1); ERAP2 (endoplasmic reticulum aminopeptidase 2); and LNPEP (leucyl and cystinyl aminopeptidase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG5849 in Genome Data Viewer
Location:
93F7-93F8; 3-73 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21740105..21744431)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17565827..17570153)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of dPsa, the Drosophila orthologue of puromycin-sensitive aminopeptidase, suggests redundancy of aminopeptidases. Schulz C, et al. Dev Genes Evol, 2001 Dec. PMID 11819115
  2. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
  3. Drosophila sperm proteome evolution: Insights from comparative genomic approaches. Rettie EC, et al. Spermatogenesis, 2012 Jul 1. PMID 23087838, Free PMC Article
  4. RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1. Jones CI, et al. Nucleic Acids Res, 2016 Jan 8. PMID 26656493, Free PMC Article
  5. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5849-PA
CG5849-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21740105..21744431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170208.2 → NP_001163679.1  uncharacterized protein Dmel_CG5849, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163679.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIS5
    Conserved Domains (2) summary
    cd09601
    Location:38 → 449
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:30 → 423
    Peptidase_M1; Peptidase family M1

  2. NM_142722.1 → NP_650979.1  uncharacterized protein Dmel_CG5849, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD87
    Related
    FBpp0083523, FBtr0084125
    Conserved Domains (3) summary
    cd09601
    Location:38 → 497
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:30 → 423
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:570 → 841
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIS5 E1JIS5
Q8MZ08 Q8MZ08
Q9VD87 Q9VD87

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