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Burs Bursicon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42560, updated on 10-May-2024

Summary

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Official Symbol
Bursprovided by FlyBase
Official Full Name
Bursiconprovided by FlyBase
Primary source
FLYBASE:FBgn0038901
Locus tag
Dmel_CG13419
See related
AllianceGenome:FB:FBgn0038901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bur alpha; burs; BURS; burs alpha; Burs alpha; burs-alpha; Burs-alpha; BursA; bursalpha; Bursalpha; Bursicon alpha; Bursicon-alpha; CG13419; Dmel\CG13419; frl; tBur
Summary
Enables hormone activity and protein heterodimerization activity. Contributes to neuropeptide hormone activity and neuropeptide receptor binding activity. Involved in several processes, including cuticle pigmentation; intestinal stem cell homeostasis; and ovarian follicle cell development. Located in extracellular region and terminal bouton. Part of bursicon neuropeptide hormone complex. Is expressed in several structures, including adult midgut; central nervous system; corpus cardiacum; larval thoracic segment; and neuromuscular junction. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Burs in Genome Data Viewer
Location:
93F9-93F9; 3-73 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21769518..21770279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17595240..17596001)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene metabotropic GABA-B receptor subtype 2 Neighboring gene uncharacterized protein Neighboring gene RNA polymerase I subunit H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cellular localization of bursicon using antisera against partial peptide sequences of this insect cuticle-sclerotizing neurohormone. Honegger HW, et al. J Comp Neurol, 2002 Oct 14. PMID 12271490
  2. Eclosion gates progression of the adult ecdysis sequence of Drosophila. Peabody NC, et al. J Exp Biol, 2013 Dec 1. PMID 24031052, Free PMC Article
  3. The downregulation of the miniature gene does not replicate miniature loss-of-function phenotypes in Drosophila melanogaster wing to the full extent. Bilousov OO, et al. Tsitol Genet, 2013 Mar-Apr. PMID 23745366
  4. Command and compensation in a neuromodulatory decision network. Luan H, et al. J Neurosci, 2012 Jan 18. PMID 22262886, Free PMC Article
  5. Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β. Scopelliti A, et al. Cell Cycle, 2016 Jun 17. PMID 27191973, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bursicon-alpha subunit modulates LGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-beta.
    Title: Bursicon-α subunit modulates dLGR2 activity in the adult Drosophila melanogaster midgut independently to Bursicon-β.
  2. acts in cuticle synthesis and degradation by regulating the expression of cuticular protein and chitin metabolizing related genes
    Title: The neuropeptide bursicon acts in cuticle metabolism.
  3. results show that the functions thought to be subserved by CCAP are partially effected by bursicon, and that bursicon plays an important and heretofore undescribed role in ecdysis behavior itself.
    Title: Genetic analysis of ecdysis behavior in Drosophila reveals partially overlapping functions of two unrelated neuropeptides.
  4. Study provides evidence that bursicon release can precede the initiation of larval ecdysis, and that bursicon tans the puparium; results establish bursicon signaling as essential to insect growth and development.
    Title: The essential role of bursicon during Drosophila development.
  5. the results of this study reveal novel neuromodulatory functions for bursicon and support the hypothesis that the BSEG are essential for orchestrating both the behavioral and somatic processes underlying wing expansion.
    Title: Bursicon functions within the Drosophila CNS to modulate wing expansion behavior, hormone secretion, and cell death.
  6. the Bursicon/Rickets signaling pathway is necessary for both wing expansion and initiation of the EMT that leads to removal of the epithelial cells from the wing.
    Title: Bursicon signaling mutations separate the epithelial-mesenchymal transition from programmed cell death during Drosophila melanogaster wing maturation.
  7. identify here Drosophila bioactive bursicon as a heterodimer made of two cystine knot polypeptides
    Title: Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2.
  8. Bursicon is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
    Title: Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hormone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to neuropeptide hormone activity IC
Inferred by Curator
more info
 PubMed 
contributes_to neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to neuropeptide receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in border follicle cell delamination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based cuticle sclerotization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sequestering of BMP from receptor via BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of bursicon neuropeptide hormone complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of bursicon neuropeptide hormone complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bursicon
Names
Burs-PA
CG13419-PA
bursicon alpha
bursicon alpha subunit
bursicon alpha-subunit
furled wing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21769518..21770279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142726.2 → NP_650983.1  bursicon [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650983.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0APJ5, Q573B6, Q9VD83
    UniProtKB/TrEMBL
    C0MK54
    Related
    FBpp0083529
    Conserved Domains (1) summary
    cl21545
    Location:50 → 138
    GHB_like; Glycoprotein hormone beta chain homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VD83.1 Q9VD83

Gene LinkOut

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