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pit pitchoune [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42595, updated on 10-May-2024

Summary

Official Symbol
pitprovided by FlyBase
Official Full Name
pitchouneprovided by FlyBase
Primary source
FLYBASE:FBgn0266581
Locus tag
Dmel_CG6375
See related
AllianceGenome:FB:FBgn0266581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6375; DDX18; Dmel\CG6375; DmRH15; hel93F; Hel93F; Pit; PIT
Summary
Predicted to enable RNA helicase activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; germ layer; gonad; and gut section. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See pit in Genome Data Viewer
Location:
94A1-94A1; 3-74 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22034298..22038925)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17860020..17864647)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-G38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fas-associated death domain Neighboring gene held out wings Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pitchoune
Names
CG6375-PA
CG6375-PB
CG6375-PC
helicase at 93F
pit-PA
pit-PB
pit-PC
NP_001287459.1
NP_524446.3
NP_732694.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    22034298..22038925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169991.2NP_732694.2  pitchoune, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732694.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V384, O77001, Q8SYP5, Q9VD51
    UniProtKB/TrEMBL
    A0A0B4LHF7
    Related
    FBpp0083572
    Conserved Domains (4) summary
    COG0513
    Location:186677
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:408537
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:187394
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:569627
    DUF4217; Domain of unknown function (DUF4217)
  2. NM_001300530.1NP_001287459.1  pitchoune, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287459.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V384, O77001, Q8SYP5, Q9VD51
    UniProtKB/TrEMBL
    A0A0B4LHF7
    Conserved Domains (4) summary
    COG0513
    Location:186677
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:408537
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:187394
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:569627
    DUF4217; Domain of unknown function (DUF4217)
  3. NM_079722.4NP_524446.3  pitchoune, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524446.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V384, O77001, Q8SYP5, Q9VD51
    UniProtKB/TrEMBL
    A0A0B4LHF7
    Related
    FBpp0083573
    Conserved Domains (4) summary
    COG0513
    Location:186677
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:408537
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:187394
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:569627
    DUF4217; Domain of unknown function (DUF4217)