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XNP [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43080, updated on 19-Jun-2024

Summary

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Official Symbol
XNPprovided by FlyBase
Primary source
FLYBASE:FBgn0039338
Locus tag
Dmel_CG4548
See related
AllianceGenome:FB:FBgn0039338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATR-X/XNP; atrx; ATRX; CG4548; DATR-X; datrx; dATRX; DATRX; Dmel\CG4548; dXNP; EP(3)0635; EP635; xnp; Xnp; xnp/atr-x; XNP/dATRX
Summary
Enables ATP hydrolysis activity and DNA translocase activity. Involved in several processes, including chromatin assembly; neurogenesis; and regulation of JNK cascade. Located in germinal vesicle. Colocalizes with beta-heterochromatin. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; extended germ band embryo; germ layer; and germline cell. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See XNP in Genome Data Viewer
Location:
96E1-96E2; 3-88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25477868..25482834, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21303590..21308556, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 33B Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glyceronephosphate O-acyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Yadav S, et al. Proc Natl Acad Sci U S A, 2019 Mar 12. PMID 30804200, Free PMC Article
  2. Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. López-Falcón B, et al. PLoS One, 2014. PMID 25437195, Free PMC Article
  3. ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. Lee J, et al. Cell Death Differ, 2012 Jul. PMID 22240898, Free PMC Article
  4. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres. Chavez J, et al. Chromosoma, 2017 Dec. PMID 28688038
  5. Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. Emelyanov AV, et al. J Biol Chem, 2010 May 14. PMID 20154359, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA translocase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA translocase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pericentric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in germinal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
XNP
Names
CG4548-PA
CG4548-PB
CG4548-PC
CG4548-PD
XNP-PA
XNP-PB
XNP-PC
XNP-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25477868..25482834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170228.3 → NP_733107.1  XNP, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733107.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3E4, Q9GQN5, Q9VBQ8
    Related
    FBpp0084212
    Conserved Domains (4) summary
    cd00046
    Location:483 → 646
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:458 → 779
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:913 → 1035
    Helicase_C; Helicase conserved C-terminal domain
    pfam08070
    Location:258 → 335
    DTHCT; DTHCT (NUC029) region

  2. NM_001300598.1 → NP_001287527.1  XNP, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHR3
    Conserved Domains (4) summary
    cd00046
    Location:218 → 381
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:193 → 514
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:648 → 770
    Helicase_C; Helicase conserved C-terminal domain
    pfam14797
    Location:3 → 84
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

  3. NM_143141.4 → NP_651398.1  XNP, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651398.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3E4, Q9GQN5, Q9VBQ8
    Related
    FBpp0084213
    Conserved Domains (4) summary
    cd00046
    Location:483 → 646
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:458 → 779
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:913 → 1035
    Helicase_C; Helicase conserved C-terminal domain
    pfam08070
    Location:258 → 335
    DTHCT; DTHCT (NUC029) region

  4. NM_001300599.1 → NP_001287528.1  XNP, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287528.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LHR3
    Conserved Domains (4) summary
    cd00046
    Location:218 → 381
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:193 → 514
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:648 → 770
    Helicase_C; Helicase conserved C-terminal domain
    pfam14797
    Location:3 → 84
    SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LHR3 A0A0B4LHR3
Q8T9C9 Q8T9C9
Q9GQN5.2 Q9GQN5

Gene LinkOut

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