U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG6295 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43247, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
CG6295provided by FlyBase
Primary source
FLYBASE:FBgn0039471
Locus tag
Dmel_CG6295
See related
AllianceGenome:FB:FBgn0039471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmelL6; Dmel\CG6295
Summary
Enables serine hydrolase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H); LIPI (lipase I); and PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG6295 in Genome Data Viewer
Location:
97D13-97D13; 3-92 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27005899..27007055, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22831621..22832777, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila. Kohyama-Koganeya A, et al. PLoS One, 2017. PMID 28045997, Free PMC Article
  2. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Sociale M, et al. Cell Rep, 2018 Jan 23. PMID 29386138
  3. Other ways to skin a cat: activating SREBP without Scap. Ozdemir C, et al. Fly (Austin), 2011 Jan-Mar. PMID 20935466, Free PMC Article
  4. Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. Matthews KA, et al. Genetics, 2009 Jan. PMID 19015545, Free PMC Article
  5. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Kunte AS, et al. Cell Metab, 2006 Jun. PMID 16753579

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables serine hydrolase activity HDA PubMed 
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG6295-PA
triglyceride lipase
NP_651521.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27005899..27007055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143264.2 → NP_651521.1  uncharacterized protein Dmel_CG6295 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB93
    Related
    FBpp0084449, FBtr0085077
    Conserved Domains (1) summary
    cd00707
    Location:64 → 330
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB93 Q9VB93

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Tools
Miscellaneous