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CG17191 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43249, updated on 10-May-2024

Summary

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Official Symbol
CG17191provided by FlyBase
Primary source
FLYBASE:FBgn0039473
Locus tag
Dmel_CG17191
See related
AllianceGenome:FB:FBgn0039473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmelL4; Dmel\CG17191
Summary
Predicted to enable lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H); LIPI (lipase I); and PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG17191 in Genome Data Viewer
Location:
97D14-97D14; 3-92 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27018608..27019751, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22844330..22845473, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for transgenerational metabolic programming in Drosophila. Buescher JL, et al. Dis Model Mech, 2013 Sep. PMID 23649823, Free PMC Article
  2. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
  3. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
  4. Molecular landscape of modified histones in Drosophila heterochromatic genes and euchromatin-heterochromatin transition zones. Yasuhara JC, et al. PLoS Genet, 2008 Jan. PMID 18208336, Free PMC Article
  5. Multiple tandem gene duplications in a neutral lipase gene cluster in Drosophila. Horne I, et al. Gene, 2008 Mar 31. PMID 18262735

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG17191-PA
triglyceride lipase
NP_651523.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27018608..27019751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143266.1 → NP_651523.1  uncharacterized protein Dmel_CG17191 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651523.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB91
    Related
    FBpp0084522, FBtr0085152
    Conserved Domains (1) summary
    cd00707
    Location:62 → 328
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VB91 Q9VB91

Gene LinkOut

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