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CG6277 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43251, updated on 10-May-2024

Summary

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Official Symbol
CG6277provided by FlyBase
Primary source
FLYBASE:FBgn0039475
Locus tag
Dmel_CG6277
See related
AllianceGenome:FB:FBgn0039475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmelL2; Dmel\CG6277
Summary
Predicted to enable lipase activity. Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG6277 in Genome Data Viewer
Location:
97D14-97D14; 3-92 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27022071..27023217, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22847793..22848939, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TweedleT

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Sociale M, et al. Cell Rep, 2018 Jan 23. PMID 29386138
  2. Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe. Mattila J, et al. Cell Rep, 2015 Oct 13. PMID 26440885
  3. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Ryuda M, et al. Zoolog Sci, 2008 Jul. PMID 18828662
  4. Survival response to increased ceramide involves metabolic adaptation through novel regulators of glycolysis and lipolysis. Nirala NK, et al. PLoS Genet, 2013 Jun. PMID 23818862, Free PMC Article
  5. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Musselman LP, et al. Dis Model Mech, 2011 Nov. PMID 21719444, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6277-PA
triglyceride lipase
NP_651525.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27022071..27023217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143268.2 → NP_651525.1  uncharacterized protein Dmel_CG6277 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VB89
    Related
    FBpp0084520
    Conserved Domains (1) summary
    cd00707
    Location:68 → 333
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXQ6 Q8SXQ6
Q9VB89 Q9VB89

Gene LinkOut

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