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Nep5 Neprilysin 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43255, updated on 10-May-2024

Summary

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Official Symbol
Nep5provided by FlyBase
Official Full Name
Neprilysin 5provided by FlyBase
Primary source
FLYBASE:FBgn0039478
Locus tag
Dmel_CG6265
See related
AllianceGenome:FB:FBgn0039478
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6265; Dmel\CG6265; DmeNEP5; nep5; NEP5
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in adult brain and spermatozoon. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Nep5 in Genome Data Viewer
Location:
97E1-97E1; 3-92 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27057908..27064199, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22883630..22889921, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene RYamide receptor Neighboring gene uncharacterized protein Neighboring gene TweedleT Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spatzle Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. Iijima-Ando K, et al. J Biol Chem, 2008 Jul 4. PMID 18463098, Free PMC Article
  2. The Drosophila Neprilysin 4 gene is essential for sperm function following sperm transfer to females. Ohsako T, et al. Genes Genet Syst, 2021 Dec 16. PMID 34556622
  3. Neprilysins: an evolutionarily conserved family of metalloproteases that play important roles in reproduction in Drosophila. Sitnik JL, et al. Genetics, 2014 Mar. PMID 24395329, Free PMC Article
  4. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  5. Drosophila metalloproteases in development and differentiation: the role of ADAM proteins and their relatives. Meyer H, et al. Eur J Cell Biol, 2011 Sep. PMID 21684629

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neprilysin 5
Names
CG6265-PC
CG6265-PD
CG6265-PE
CG6265-PF
Nep5-PC
Nep5-PD
Nep5-PE
Nep5-PF
NP_001097940.1
NP_001287554.1
NP_651527.3
NP_733186.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27057908..27064199 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300625.1 → NP_001287554.1  neprilysin 5, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287554.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHC6, Q9VB85
    Conserved Domains (1) summary
    cd08662
    Location:151 → 699
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

  2. NM_170307.2 → NP_733186.2  neprilysin 5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733186.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMQ2
    Conserved Domains (2) summary
    cd08662
    Location:151 → 880
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    COG3590
    Location:146 → 882
    PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

  3. NM_143270.3 → NP_651527.3  neprilysin 5, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651527.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHC6, Q9VB85
    Conserved Domains (1) summary
    cd08662
    Location:151 → 699
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

  4. NM_001104470.2 → NP_001097940.1  neprilysin 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHC6, Q9VB85
    Conserved Domains (1) summary
    cd08662
    Location:151 → 699
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IHC6 Q8IHC6
Q8IMQ2 Q8IMQ2
Q95SM2 Q95SM2

Gene LinkOut

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