Mfsd2b MFSD2 lysolipid transporter B, sphingolipid [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mfsd2bprovided by MGI
Official Full Name: MFSD2 lysolipid transporter B, sphingolipidprovided by MGI
Primary source: MGI:MGI:3583946
See related: Ensembl:ENSMUSG00000037336 AllianceGenome:MGI:3583946
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm1964
Summary: Enables sphingolipid transporter activity. Involved in lipid transport. Is integral component of plasma membrane. Is expressed in liver lobe. Orthologous to human MFSD2B (major facilitator superfamily domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14.5 (RPKM 21.0), liver E14 (RPKM 17.3) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 2.11 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4912438..4924359, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (4862438..4874359, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction.
Title: Revealing concealed cardioprotection by platelet Mfsd2b-released S1P in human and murine myocardial infarction.
Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
Title: Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock.
Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.
Title: Erythrocytes efficiently utilize exogenous sphingosines for S1P synthesis and export via Mfsd2b.
Deletion of Mfsd2b impairs thrombotic functions of platelets.
Title: Deletion of Mfsd2b impairs thrombotic functions of platelets.
Using microarray analysis of erythroid cell lines overexpressing human and mouse MFSD2B study showed sphingosine 1-phosphate (S1P) transport activity. The properties of S1P release by MFSD2B were similar to those in erythrocytes. Moreover, knockout of MFSD2B in MEDEP-E14 cells decreased S1P export from the cells. These results strongly suggest that MFSD2B is a novel S1P transporter in erythroid cells.
Title: MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells.
S1P secretion by Mfsd2b is critical for red blood cell morphology; data reveal an unexpected physiological role of red blood cells in sphingolipid metabolism in circulation; findings open new avenues for investigating the signalling roles of S1P derived from red blood cells and platelets
Title: Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets.
Results identify Mfsd2a (major facilitator superfamily domain-containing protein 2a) and an additional closely related protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive thermogenesis.
Title: Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

D5Mit392.1 (e-PCR), detects polymorphism
- UniSTS:130544

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sphingolipid transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingolipid transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingolipid transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sphingolipid transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingosine-1-phosphate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sphingosine-1-phosphate transporter MFSD2B

Names: mMfsd2b; major facilitator superfamily domain containing 2B; major facilitator superfamily domain-containing protein 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033488.2 → NP_001028660.2 sphingosine-1-phosphate transporter MFSD2B

Status: VALIDATED

Source sequence(s)

CT571254

Consensus CDS

CCDS36401.2

UniProtKB/Swiss-Prot

Q3T9M1, Q3TRN2, Q3U198

UniProtKB/TrEMBL

B8JK43

Related

ENSMUSP00000045315.8, ENSMUST00000045921.14

Conserved Domains (2) summary

pfam13347
Location:34 → 467

MFS_2; MFS/sugar transport protein

cl21472
Location:26 → 467

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

4912438..4924359 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515146.2 → XP_006515209.1 sphingosine-1-phosphate transporter MFSD2B isoform X1

UniProtKB/TrEMBL

B8JK42

Related

ENSMUSP00000117057.2, ENSMUST00000137337.8

Conserved Domains (1) summary

cl28910
Location:2 → 363

MFS; Major Facilitator Superfamily