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Acsl5 acyl-CoA synthetase long-chain family member 5 [ Mus musculus (house mouse) ]

Gene ID: 433256, updated on 11-Apr-2024

Summary

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Official Symbol
Acsl5provided by MGI
Official Full Name
acyl-CoA synthetase long-chain family member 5provided by MGI
Primary source
MGI:MGI:1919129
See related
Ensembl:ENSMUSG00000024981 AllianceGenome:MGI:1919129
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ACS2; ACS5; Facl5; 1700030F05Rik
Summary
Enables long-chain fatty acid-CoA ligase activity. Involved in long-chain fatty acid metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 62.0), large intestine adult (RPKM 51.5) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D2; 19 51.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (55240298..55285060)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (55251861..55296628)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46491 Neighboring gene microRNA 6715 Neighboring gene tectorin beta Neighboring gene STARR-seq mESC enhancer starr_46492 Neighboring gene guanylate cyclase 2g Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:55328374-55328561 Neighboring gene STARR-positive B cell enhancer ABC_E8758 Neighboring gene predicted gene, 31595 Neighboring gene STARR-positive B cell enhancer ABC_E7673 Neighboring gene zinc finger, DHHC domain containing 6 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene STARR-seq mESC enhancer starr_46494 Neighboring gene STARR-seq mESC enhancer starr_46495 Neighboring gene STARR-seq mESC enhancer starr_46496 Neighboring gene STARR-seq mESC enhancer starr_46497 Neighboring gene STARR-seq mESC enhancer starr_46499 Neighboring gene STARR-positive B cell enhancer ABC_E2531 Neighboring gene STARR-positive B cell enhancer ABC_E2532

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats. Luo F, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 34923175, Free PMC Article
  2. Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. Bowman TA, et al. Mol Metab, 2016 Mar. PMID 26977393, Free PMC Article
  3. Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption. Meller N, et al. Lipids Health Dis, 2013 Jun 14. PMID 23767941, Free PMC Article
  4. Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation. Hou T, et al. Mol Cell, 2022 Nov 3. PMID 36208627
  5. Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. Marszalek JR, et al. J Biol Chem, 2004 Jun 4. PMID 15051725

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
    Title: Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.
  2. Acsl5 is a major activator of dietary long chain fatty acids , yet in Acsl5 KO mice residual ACS activity is sufficient for maintaining a normal long chain fatty acids absorption.
    Title: Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption.
  3. Acyl-CoA synthetase 2 has a role in fatty acid internalization and neurite outgrowth
    Title: Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid-CoA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables long-chain fatty acid-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oleoyl-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty-acyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of long-chain fatty acid import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
long-chain-fatty-acid--CoA ligase 5
Names
LACS 5
arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 5
long-chain acyl-CoA synthetase 5
NP_082252.1
XP_006527241.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027976.2 → NP_082252.1  long-chain-fatty-acid--CoA ligase 5

    See identical proteins and their annotated locations for NP_082252.1

    Status: VALIDATED

    Source sequence(s)
    AC133100, AI838021, BC031544
    Consensus CDS
    CCDS29908.1
    UniProtKB/Swiss-Prot
    Q8JZR0
    UniProtKB/TrEMBL
    Q3UC67, Q3UKS0
    Related
    ENSMUSP00000046585.5, ENSMUST00000043150.6
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    55240298..55285060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527178.4 → XP_006527241.1  long-chain-fatty-acid--CoA ligase 5 isoform X1

    See identical proteins and their annotated locations for XP_006527241.1

    UniProtKB/Swiss-Prot
    Q8JZR0
    UniProtKB/TrEMBL
    Q3UC67, Q3UKS0
    Conserved Domains (1) summary
    cd05927
    Location:101 → 678
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZR0.1 GenPept UniProtKB/Swiss-Prot:Q8JZR0

Gene LinkOut

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