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mil milkah [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43343, updated on 10-May-2024

Summary

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Official Symbol
milprovided by FlyBase
Official Full Name
milkahprovided by FlyBase
Primary source
FLYBASE:FBgn0267366
Locus tag
Dmel_CG5017
See related
AllianceGenome:FB:FBgn0267366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5017; Dmel\CG5017; hanabi; Mil; tNAP
Summary
Enables histone binding activity. Involved in several processes, including male courtship behavior; memory; and nucleosome assembly. Located in Nebenkern and cytosol. Is expressed in adult head; spermatozoon; and testis. Orthologous to several human genes including NAP1L2 (nucleosome assembly protein 1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See mil in Genome Data Viewer
Location:
98B5-98B5; 3-94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27912447..27913785)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23738169..23739507)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 98a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S22 Neighboring gene Buddy of Hmr 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster]. Kuzin BA, et al. Ontogenez, 2010 Sep-Oct. PMID 21061663
  2. Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification. Kuzin BA, et al. PLoS One, 2014. PMID 24736732, Free PMC Article
  3. The Drosophila chromosomal protein Mst77F is processed to generate an essential component of mature sperm chromatin. Kimura S, et al. Open Biol, 2016 Nov. PMID 27810970, Free PMC Article
  4. The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis. Kimura S. FEBS Lett, 2013 Apr 2. PMID 23454210
  5. Recurrent Innovation at Genes Required for Telomere Integrity in Drosophila. Lee YC, et al. Mol Biol Evol, 2017 Feb 1. PMID 27836984, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate the essential roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in spermatogenesis
    Title: The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.
  2. Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster
    Title: [Interaction of the ss and CG5017 genes in the regulation of morphogensis of limbs in Drosophila melanogaster].
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Nebenkern IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
milkah
Names
CG5017-PA
hanabi
mil-PA
milkah-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    27912447..27913785
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143335.2 → NP_651592.2  milkah [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651592.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZC3, Q9VAZ1
    Related
    FBpp0084615
    Conserved Domains (1) summary
    pfam00956
    Location:37 → 251
    NAP; Nucleosome assembly protein (NAP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VAZ1 Q9VAZ1

Gene LinkOut

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