Jmjd7 jumonji domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jmjd7provided by MGI
Official Full Name: jumonji domain containing 7provided by MGI
Primary source: MGI:MGI:3845785
See related: Ensembl:ENSMUSG00000098789 AllianceGenome:MGI:3845785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including 2-oxoglutarate-dependent dioxygenase activity; methylated histone binding activity; and peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm and nucleus. Is expressed in alimentary system; axial skeleton; nervous system; respiratory system; and urinary system. Orthologous to several human genes including JMJD7 (jumonji domain containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 12.1), CNS E14 (RPKM 11.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.09 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119857964..119863085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (120027483..120032604)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recognition between JMJD5/JMJD7 and histone substrates is specific, which is reflected by the binding data between enzymes and substrates. High structural similarity between JMJD5 and JMJD7 is reflected by the shared common substrates and high binding affinity.
Title: Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AW123212 (e-PCR)
- UniSTS:178694

Pla2g4b (e-PCR), detects polymorphism
- UniSTS:546948

Readthrough Gm28042

Readthrough gene: Gm28042, Included gene: Pla2g4b

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-lysine 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein hydroxylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7

Names: L-lysine (3S)-hydroxylase Jmjd7; jmjC domain-containing protein 7; jumonji domain-containing protein 7

NP_001108109.1

EC 1.14.11.63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.