Wfdc6b WAP four-disulfide core domain 6B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc6bprovided by MGI
Official Full Name: WAP four-disulfide core domain 6Bprovided by MGI
Primary source: MGI:MGI:3575430
See related: Ensembl:ENSMUSG00000070531 AllianceGenome:MGI:3575430
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: WAP6b; Wfdc6
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human EPPIN-WFDC6 (EPPIN-WFDC6 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 82.5) See more
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Genomic context

Location:: 2 H3; 2 85.22 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164455431..164460133)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164613511..164618213)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of peptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 6B

Names: WAP four-disulfide core 6-like 1; putative protease inhibitor WAP6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012725.3 → NP_001012743.2 WAP four-disulfide core domain protein 6B precursor

See identical proteins and their annotated locations for NP_001012743.2

Status: VALIDATED

Source sequence(s)

AL591478

Consensus CDS

CCDS17046.2

UniProtKB/Swiss-Prot

B2RUM4, E9Q6A8, F6ULY1, Q5DQU6

Related

ENSMUSP00000091906.3, ENSMUST00000094346.3

Conserved Domains (2) summary

pfam00014
Location:87 → 138

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00095
Location:42 → 82

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

164455431..164460133

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499875.2 → XP_006499938.1 WAP four-disulfide core domain protein 6B isoform X1

Conserved Domains (2) summary

pfam00014
Location:94 → 145

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam00095
Location:63 → 89

WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'