U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnf207 ring finger protein 207 [ Mus musculus (house mouse) ]

Gene ID: 433809, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rnf207provided by MGI
Official Full Name
ring finger protein 207provided by MGI
Primary source
MGI:MGI:2684989
See related
Ensembl:ENSMUSG00000058498 AllianceGenome:MGI:2684989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm143; D330010C22Rik
Summary
Predicted to enable Hsp70 protein binding activity; chaperone binding activity; and transmembrane transporter binding activity. Predicted to be involved in several processes, including positive regulation of voltage-gated potassium channel activity; regulation of cardiac muscle contraction; and regulation of heart looping. Predicted to be located in cytoplasm. Predicted to be active in perinuclear region of cytoplasm. Orthologous to human RNF207 (ring finger protein 207). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 22.3), thymus adult (RPKM 12.6) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 E2; 4 83.02 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (152391475..152403686, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (152307018..152319076, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6292 Neighboring gene STARR-seq mESC enhancer starr_12200 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene STARR-positive B cell enhancer ABC_E9627 Neighboring gene STARR-positive B cell enhancer ABC_E4736 Neighboring gene G protein-coupled receptor 153 Neighboring gene STARR-positive B cell enhancer ABC_E3558 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene RIKEN cDNA 9430083M05 gene Neighboring gene isoprenylcysteine carboxyl methyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E846 Neighboring gene ribosomal protein L22 Neighboring gene chromodomain helicase DNA binding protein 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. Mizushima W, et al. J Mol Cell Cardiol, 2016 Nov. PMID 27677939
  2. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
  3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
    Title: RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1.
  2. Our findings indicate that RNF207 is involved in ATP production by cardiomyocytes, suggesting that RNF207 plays an important role in the development of heart failure.
    Title: The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of heart looping IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RING finger protein 207

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033489.2 → NP_001028661.2  RING finger protein 207

    See identical proteins and their annotated locations for NP_001028661.2

    Status: VALIDATED

    Source sequence(s)
    AK042379, AK052224, BQ553878
    Consensus CDS
    CCDS51393.1
    UniProtKB/Swiss-Prot
    A6PW94, Q3V3A7
    UniProtKB/TrEMBL
    B9EJ04
    Related
    ENSMUSP00000075540.6, ENSMUST00000076183.12
    Conserved Domains (3) summary
    smart00502
    Location:202 → 321
    BBC; B-Box C-terminal domain
    cd16558
    Location:22 → 64
    RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
    cd19814
    Location:97 → 150
    Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    152391475..152403686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539010.5 → XP_006539073.1  RING finger protein 207 isoform X2

    UniProtKB/TrEMBL
    B9EJ04
    Conserved Domains (3) summary
    smart00502
    Location:202 → 321
    BBC; B-Box C-terminal domain
    cd16558
    Location:22 → 64
    RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
    cd19814
    Location:97 → 150
    Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

  2. XM_011250295.4 → XP_011248597.1  RING finger protein 207 isoform X1

    UniProtKB/TrEMBL
    B9EJ04
    Conserved Domains (2) summary
    cd16558
    Location:22 → 64
    RING-HC_RNF207; RING finger, HC subclass, found in RING finger protein 207 (RNF207) and similar proteins
    cd19814
    Location:97 → 150
    Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

  3. XM_011250296.2 → XP_011248598.1  RING finger protein 207 isoform X3

    UniProtKB/TrEMBL
    B9EJ04
    Conserved Domains (1) summary
    cd19814
    Location:5 → 48
    Bbox1_RNF207-like; B-box-type 1 zinc finger found in RING finger protein 207 (RNF207) and similar proteins

  4. XM_011250297.2 → XP_011248599.1  RING finger protein 207 isoform X4

  5. XM_030253643.1 → XP_030109503.1  RING finger protein 207 isoform X5

  6. XM_011250298.4 → XP_011248600.1  RING finger protein 207 isoform X5

RNA

  1. XR_003954979.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3V3A7.2 GenPept UniProtKB/Swiss-Prot:Q3V3A7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous