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MOS MOS proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 4342, updated on 5-Mar-2024

Summary

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Official Symbol
MOSprovided by HGNC
Official Full Name
MOS proto-oncogene, serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:7199
See related
Ensembl:ENSG00000172680 MIM:190060; AllianceGenome:HGNC:7199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSV; OZEMA20
Summary
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Orthologs
mouse all
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Genomic context

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See MOS in Genome Data Viewer
Location:
8q12.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (56112942..56113982, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (56489918..56490958, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (57025501..57026541, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene competing endogenous lncRNA 3 for miR-645 Neighboring gene nucleophosmin 1 pseudogene 21 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:57025920-57026420 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:57030128-57030628 Neighboring gene uncharacterized LOC124900263 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:57054775-57055317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19210 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:57079228-57080427 Neighboring gene PLAG1 zinc finger Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27399 Neighboring gene MPRA-validated peak7026 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:57124219-57124444

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MOS mutation causes female infertility with large polar body oocytes. Jiao G, et al. Gynecol Endocrinol, 2022 Dec. PMID 36403623
  2. Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study. Shin CM, et al. Int J Cancer, 2013 Nov. PMID 23595635
  3. Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae. Shin CM, et al. J Pathol, 2012 Mar. PMID 22252584
  4. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. Prasad CK, et al. Mol Reprod Dev, 2008 Aug. PMID 18246541, Free PMC Article
  5. Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. Kalejs M, et al. BMC Cancer, 2006 Jan 9. PMID 16401344, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MOS mutation causes female infertility with large polar body oocytes.
    Title: MOS mutation causes female infertility with large polar body oocytes.
  2. approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1.
    Title: Genetic modifiers of EGFR dependence in non-small cell lung cancer.
  3. High methylation level in MOS is associated with intestinal metaplasia.
    Title: Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study.
  4. among the candidate genes, DNA methylation of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of gastric cancer.
    Title: Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.
  6. In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects.
    Title: Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.
  7. Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition
    Title: Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition.
  8. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
    Title: Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation.
  9. These results clarify the direct link of the classical Mos-MAPK (mitogen-activated protein kinase) pathway to Erp1 in meiotic arrest of vertebrate oocytes.
    Title: A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs.
  10. the Mos/MAPK pathway is not essential for initiating goldfish oocyte maturation despite its general function as a cytostatic factor (CSF).
    Title: The Mos/MAPK pathway is involved in metaphase II arrest as a cytostatic factor but is neither necessary nor sufficient for initiating oocyte maturation in goldfish.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Oocyte/zygote/embryo maturation arrest 20
MedGen: C5830539 OMIM: 620383 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of v-mos Moloney murine sarcoma viral oncogene homolog (MOS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119962, MGC119963

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of meiotic spindle orientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in meiotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of metaphase/anaphase transition of meiotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proto-oncogene serine/threonine-protein kinase mos
Names
c-mos
oncogene MOS, Moloney murine sarcoma virus
oocyte maturation factor mos
proto-oncogene c-Mos
v-mos Moloney murine sarcoma viral oncogene homolog
NP_005363.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005372.1 → NP_005363.1  proto-oncogene serine/threonine-protein kinase mos

    See identical proteins and their annotated locations for NP_005363.1

    Status: VALIDATED

    Source sequence(s)
    AC107376
    Consensus CDS
    CCDS6164.1
    UniProtKB/Swiss-Prot
    P00540, Q3KPG9, Q3KPH0
    Related
    ENSP00000310722.1, ENST00000311923.1
    Conserved Domains (1) summary
    cd13979
    Location:56 → 338
    STKc_Mos; Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    56112942..56113982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    56489918..56490958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00540.1 GenPept UniProtKB/Swiss-Prot:P00540

Gene LinkOut

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