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Ctl2 Choline transporter-like 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43440, updated on 10-May-2024

Summary

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Official Symbol
Ctl2provided by FlyBase
Official Full Name
Choline transporter-like 2provided by FlyBase
Primary source
FLYBASE:FBgn0039637
Locus tag
Dmel_CG11880
See related
AllianceGenome:FB:FBgn0039637
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11880; CTLH2; DmCTL2; Dmel\CG11880
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. Is expressed in adult head and dorsal median cell. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to several human genes including SLC44A2 (solute carrier family 44 member 2) and SLC44A5 (solute carrier family 44 member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Ctl2 in Genome Data Viewer
Location:
98F10-98F12; 3-97 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29123370..29128247)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24949092..24953969)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pyruvate dehydrogenase E1 beta subunit Neighboring gene Autophagy-related 14 Neighboring gene yemanuclein Neighboring gene dim gamma-tubulin 6 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development. Duan Y, et al. Insect Biochem Mol Biol, 2022 Feb. PMID 34982980
  2. julius seizure, a Drosophila Mutant, Defines a Neuronal Population Underlying Epileptogenesis. Horne M, et al. Genetics, 2017 Mar. PMID 28082408, Free PMC Article
  3. Molecular characterization of the family of choline transporter-like proteins and their splice variants. Traiffort E, et al. J Neurochem, 2005 Mar. PMID 15715662
  4. Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing. Garelli A, et al. Nat Commun, 2015 Oct 29. PMID 26510564, Free PMC Article
  5. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Zhang D, et al. Chromosoma, 2011 Feb. PMID 20857302

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
    Title: Choline transporter-like protein 2 interacts with chitin synthase 1 and is involved in insect cuticle development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
choline transporter-like 2
Names
CG11880-PA
CG11880-PB
CG11880-PC
Ctl2-PA
Ctl2-PB
Ctl2-PC
choline transporter (CTL)-like protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29123370..29128247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143413.2 → NP_651670.1  choline transporter-like 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651670.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAP3
    UniProtKB/TrEMBL
    C4XVJ5
    Related
    FBpp0084740
    Conserved Domains (1) summary
    pfam04515
    Location:407 → 761
    Choline_transpo; Plasma-membrane choline transporter

  2. NM_170389.2 → NP_733268.1  choline transporter-like 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAP3
    UniProtKB/TrEMBL
    C4XVJ5
    Related
    FBpp0084741
    Conserved Domains (1) summary
    pfam04515
    Location:407 → 761
    Choline_transpo; Plasma-membrane choline transporter

  3. NM_170390.2 → NP_733269.1  choline transporter-like 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733269.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAP3
    UniProtKB/TrEMBL
    C4XVJ5
    Related
    FBpp0084742
    Conserved Domains (1) summary
    pfam04515
    Location:407 → 761
    Choline_transpo; Plasma-membrane choline transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR01 Q8MR01
Q9VAP3.1 Q9VAP3

Gene LinkOut

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