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janA janus A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43569, updated on 10-May-2024

Summary

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Official Symbol
janAprovided by FlyBase
Official Full Name
janus Aprovided by FlyBase
Primary source
FLYBASE:FBgn0001280
Locus tag
Dmel_CG7933
See related
AllianceGenome:FB:FBgn0001280
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT12574; CG7933; Dmel\CG7933; jan; Jan; jan A; janus; Y
Summary
Predicted to enable protein histidine phosphatase activity. Involved in sex differentiation. Predicted to be active in cytosol. Is expressed in several structures, including extended germ band embryo; germ layer; gonad; gut section; and stage 5 embryo. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See janA in Genome Data Viewer
Location:
99D3-99D3; 3-100 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30038622..30039533, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25864344..25865255, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Axin Neighboring gene Zinc-finger protein interacting with CP190 Neighboring gene ocnus Neighboring gene janus B Neighboring gene Serendipity alpha Neighboring gene Serendipity beta Neighboring gene Serendipity delta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons. Vincent A, et al. EMBO J, 1984 May. PMID 6329730, Free PMC Article
  2. Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. Parsch J, et al. Genetics, 2001 Oct. PMID 11606541, Free PMC Article
  3. Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. Vincent A, et al. J Mol Biol, 1985 Nov 5. PMID 3935797
  4. Transcriptional and translational cis-regulatory sequences of the spermatocyte-specific Drosophila janusB gene are located in the 3' exonic region of the overlapping janusA gene. Yanicostas C, et al. Mol Gen Genet, 1990 Dec. PMID 2125114
  5. The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo. Schweisguth F, et al. Genes Dev, 1990 Jun. PMID 2166703

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein histidine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in peptidyl-histidine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sex differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
janus A
Names
CG7933-PA
CG7933-PB
CG7933-PC
janA-PA
janA-PB
janA-PC
janus
NP_788762.1
NP_788763.1
NP_996311.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30038622..30039533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206588.2 → NP_996311.1  janus A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996311.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LA86
    Conserved Domains (1) summary
    pfam05005
    Location:9 → 108
    Ocnus; Janus/Ocnus family (Ocnus)

  2. NM_176586.4 → NP_788763.1  janus A, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788763.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LA86
    Related
    FBpp0089165
    Conserved Domains (1) summary
    pfam05005
    Location:9 → 108
    Ocnus; Janus/Ocnus family (Ocnus)

  3. NM_176585.2 → NP_788762.1  janus A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788762.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V3M6, P20348, Q8T475, Q9VAB6
    UniProtKB/TrEMBL
    C7LA86
    Related
    FBpp0084962
    Conserved Domains (1) summary
    pfam05005
    Location:25 → 124
    Ocnus; Janus/Ocnus family (Ocnus)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20348.2 P20348

Gene LinkOut

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