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Ctr1C Copper transporter 1C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43668, updated on 10-May-2024

Summary

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Official Symbol
Ctr1Cprovided by FlyBase
Official Full Name
Copper transporter 1Cprovided by FlyBase
Primary source
FLYBASE:FBgn0062411
Locus tag
Dmel_CG15551
See related
AllianceGenome:FB:FBgn0062411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT31946; CG15551; Dmel\CG15551; FBgn0039813
Summary
Enables copper ion transmembrane transporter activity. Involved in copper ion import and spermatogenesis. Located in plasma membrane. Orthologous to human SLC31A1 (solute carrier family 31 member 1) and SLC31A2 (solute carrier family 31 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Ctr1C in Genome Data Viewer
Location:
100B1-100B1; 3-102 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30963290..30964320, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26789012..26790042, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7 Neighboring gene long non-coding RNA:CR46116 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila copper transporter Ctr1C functions in male fertility. Steiger D, et al. J Biol Chem, 2010 May 28. PMID 20351114, Free PMC Article
  2. Human copper transporter Ctr1 is functional in Drosophila, revealing a high degree of conservation between mammals and insects. Hua H, et al. J Biol Inorg Chem, 2010 Jan. PMID 19856191
  3. Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasis. Armstrong N, et al. PLoS One, 2013. PMID 23308159, Free PMC Article
  4. Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. Lang M, et al. Neurobiol Aging, 2013 Nov. PMID 23827522, Free PMC Article
  5. A copper-regulated transporter required for copper acquisition, pigmentation, and specific stages of development in Drosophila melanogaster. Zhou H, et al. J Biol Chem, 2003 Nov 28. PMID 12966081

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables copper ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables copper ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in copper ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in copper ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
copper transporter 1C
Names
CG15551-PA
Ctr1C-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30963290..30964320 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143580.3 → NP_651837.1  copper transporter 1C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651837.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T8R3, Q9VA22
    Related
    FBpp0085111
    Conserved Domains (2) summary
    pfam04145
    Location:63 → 258
    Ctr; Ctr copper transporter family
    pfam04592
    Location:23 → 56
    SelP_N; Selenoprotein P, N terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T8R3 Q8T8R3
Q9VA22 Q9VA22

Gene LinkOut

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Other Literature Sources
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