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CanA1 Calcineurin A1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43670, updated on 10-May-2024

Summary

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Official Symbol
CanA1provided by FlyBase
Official Full Name
Calcineurin A1provided by FlyBase
Primary source
FLYBASE:FBgn0010015
Locus tag
Dmel_CG1455
See related
AllianceGenome:FB:FBgn0010015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Can; CaN; CAN A1/PP2B; canA; canA1; Cana1; CaNA1; CG1455; CnA; CNA1; CnnA21EF; D14; DmCanA1-100B; Dmel\CG1455; pMY4; PP2B; PP2B 21EF; PpD14
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including medium-term memory; negative regulation of epidermal growth factor receptor signaling pathway; and response to nitric oxide. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in aortic valve stenosis and schizophrenia. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CanA1 in Genome Data Viewer
Location:
100B1-100B1; 3-102 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31039374..31046821)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26865096..26872543)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7 Neighboring gene long non-coding RNA:CR46117 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Alkaline phosphatase 4 Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo. Brown L, et al. FEBS Lett, 1994 Feb 14. PMID 8313960
  2. Molecular cloning and characterization of the genes encoding the two subunits of Drosophila melanogaster calcineurin. Guerini D, et al. J Biol Chem, 1992 Nov 5. PMID 1331060
  3. Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis. Habernig L, et al. PLoS Genet, 2021 Nov. PMID 34780474, Free PMC Article
  4. Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila. Zarndt R, et al. Circ Cardiovasc Genet, 2017 Oct. PMID 28986453, Free PMC Article
  5. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. Cardenas ME, et al. EMBO J, 1995 Jun 15. PMID 7540976, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activation of Ca[2+] phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
    Title: Activation of Ca(2+) phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies.
  2. Ca2+ administration prevents alpha-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
    Title: Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.
  3. Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
    Title: Minibrain kinase and calcineurin coordinate activity-dependent bulk endocytosis through synaptojanin.
  4. results suggest a key role for calcineurin in cardiac remodeling during long-term hypoxia with implications for diseases of chronic hypoxia, and it likely contributes to mechanisms underlying these disease states.
    Title: Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila.
  5. upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD.
    Title: Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling.
  6. results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation.
    Title: Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster.
  7. calcineurin, upon activation by Ca(2+)-calmodulin, cooperates with other factors to negatively regulate Egf receptor signaling at the level of sprouty and the GTPase-activating protein Gap1
    Title: The Ca(2+)-calmodulin-activated protein phosphatase calcineurin negatively regulates EGF receptor signaling in Drosophila development.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 31045753-31045869 mobile_element_type = transposon:INE-1{}3519

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in medium-term memory IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to nitric oxide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to nitric oxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
calcineurin A1
Names
CG1455-PA
CG1455-PB
CG1455-PD
CanA1-PA
CanA1-PB
CanA1-PD
calcineurin
calcineurin A
protein phosphatase D14
protein phosphatase from PCR fragment D14
NP_001247377.1
NP_001247378.2
NP_524600.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31039374..31046821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260449.2 → NP_001247378.2  calcineurin A1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247378.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48456, Q8MQN3, Q9TY69, Q9VA20
    UniProtKB/TrEMBL
    A0A0B4K6V6
    Conserved Domains (2) summary
    smart00156
    Location:98 → 369
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:81 → 385
    MPP_PP2B; PP2B, metallophosphatase domain

  2. NM_079861.4 → NP_524600.3  calcineurin A1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524600.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48456, Q8MQN3, Q9TY69, Q9VA20
    UniProtKB/TrEMBL
    A0A0B4K6V6
    Related
    FBpp0085094
    Conserved Domains (2) summary
    smart00156
    Location:98 → 369
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:81 → 385
    MPP_PP2B; PP2B, metallophosphatase domain

  3. NM_001260448.2 → NP_001247377.1  calcineurin A1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6N5
    Conserved Domains (2) summary
    smart00156
    Location:98 → 369
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:81 → 385
    MPP_PP2B; PP2B, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6N5 A0A0B4K6N5
A0A0B4K6V6 A0A0B4K6V6
P48456.2 P48456

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