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Alp4 Alkaline phosphatase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43671, updated on 10-May-2024

Summary

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Official Symbol
Alp4provided by FlyBase
Official Full Name
Alkaline phosphatase 4provided by FlyBase
Primary source
FLYBASE:FBgn0016123
Locus tag
Dmel_CG1462
See related
AllianceGenome:FB:FBgn0016123
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aph-4; Aph-4; CG1462; Dmel\CG1462; l(3)07028; pMY51
Summary
Predicted to enable alkaline phosphatase activity. Involved in epithelial fluid transport; multicellular organism reproduction; and nervous system development. Predicted to be located in cell surface and extracellular space. Is expressed in Malpighian tubule; adult head; and large field neurons. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; infantile hypophosphatasia; and inflammatory bowel disease. Orthologous to several human genes including ALPL (alkaline phosphatase, biomineralization associated); ALPG (alkaline phosphatase, germ cell); and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Alp4 in Genome Data Viewer
Location:
100B1-100B1; 3-102 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31048929..31052540)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26874651..26878262)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Calcineurin A1 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene mir-4948 stem loop Neighboring gene Coiled-coil-helix-coiled-coil-helix domain containing 3 Neighboring gene discs overgrown

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-specific expression of a type I adenylyl cyclase rescues the rutabaga mutant memory defect: in search of the engram. Zars T, et al. Learn Mem, 2000 Jan. PMID 10706599, Free PMC Article
  2. Functional dissection of the Drosophila mushroom bodies by selective feminization of genetically defined subcompartments. O'Dell KM, et al. Neuron, 1995 Jul. PMID 7619530
  3. Building the central complex in Drosophila: the generation and development of distinct neural subsets. Young JM, et al. J Comp Neurol, 2010 May 1. PMID 20187144
  4. Functional domains are specified to single-cell resolution in a Drosophila epithelium. Sözen MA, et al. Proc Natl Acad Sci U S A, 1997 May 13. PMID 9144216, Free PMC Article
  5. Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets. Young JM, et al. J Comp Neurol, 2010 May 1. PMID 20187142

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alkaline phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkaline phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial fluid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region ISM
Inferred from Sequence Model
more info
 PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
alkaline phosphatase 4
Names
Alp4-PA
Alp4-PB
CG1462-PA
CG1462-PB
alkaline phosphatase
alkaline phosphatase-4
NP_524601.2
NP_733413.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31048929..31052540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079862.3 → NP_524601.2  alkaline phosphatase 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524601.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQR2, Q24238, Q3KN28, Q8IMH0, Q8SXW6, Q9VA19
    Related
    FBpp0085095
    Conserved Domains (2) summary
    smart00098
    Location:85 → 541
    alkPPc; Alkaline phosphatase homologues
    COG1785
    Location:60 → 534
    PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]

  2. NM_170534.2 → NP_733413.1  alkaline phosphatase 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24238
    Related
    FBpp0085096
    Conserved Domains (1) summary
    smart00098
    Location:1 → 447
    alkPPc; Alkaline phosphatase homologues
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24238.3 Q24238

Gene LinkOut

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